Results 91 to 100 of about 47,957 (242)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Actividad de Aprendizaje eje 3 Hospitales Verdes I: lectura
, 2018 Es una estrategia que pretende verificar la apropiación que los estudiantes hacen de los principales conceptos, discursos, teorías o metodologías que se desarrollan en un texto relacionado con hospitales verdes.
Martinez, Viviana
core
Diagnóstico de problemáticas asistenciales en clínicas y hospitales de Barranquilla [PDF]
, 2016 Objetivo Identificar y evaluar las principales problemáticas asistenciales en clínicas y hospitales de la ciudad de Barranquilla, Colombia.Método Estudio descriptivo aplicado a población de clínicas [23] y hospitales [5]. Se utilizó un nivel de confianza
Felizzola Jimenez, Heriberto Alexander +1 more
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2014 La presente disertación tiene como finalidad el análisis de las instituciones psiquiátricas y el mundo de los internos, en su relación con el cine. Para ello, será necesario ubicar teórica e históricamente los hospitales psiquiátricos y describir las ...
Coloma Rivadeneira, Pamela Elizabeth
core +1 more source
, 2018 El curso Hospitales Verdes I se estructura en 4 ejes articulados que conducen a la comprensión de la gestión ambiental hospitalaria de un hospital verde orientada al manejo integral de los residuos y el ahorro y uso eficiente de energía eléctrica; lo ...
Martinez, Viviana
core
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Nigrostriatal iron accumulation in the progression of Parkinson’s disease
npj Parkinson's DiseaseIron deposition in the nigrostriatal system plays a pivotal role in Parkinson’s disease (PD) onset and progression. This study explored the time course of nigrostriatal iron accumulation in 54 PD patients at early to moderately advanced stages and 20 age-
M. López-Aguirre +11 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source