Results 111 to 120 of about 9,550 (245)

InguinoScrotal Hernias: Comparison of Minimally Invasive Approaches and Open Surgical Repair (The SCAR Study). [PDF]

J Abdom Wall Surg
Caruso R, Vicente E, Quijano Y, Zarate Gomez J, Porrero Guerrero B, Valdés de Anca Á, Alonso Garcia MT, Morales Taboada Á, Pastor Riquelme P, Salido Fernandez S, Serrano Gonzalez J, Morante Perea AP, Ferri V.   +12 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Humanization and Communication Skills: A Cross-Sectional Study in Spanish Nursing Students. [PDF]

Nurs Rep
Guzmán-De Santa Ana P, Serna-Menor A, Martínez-García A, Moreno-Sánchez R, Ruíz-Núñez C, García-Notario AI, Hervás-Pérez JP, Herrera-Peco I.   +7 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

763 Expanded and activated TILs kill tumor cells enabling IO compound assays

Journal for ImmunoTherapy of Cancer, 2020
Paula Comune Pennacchi, Paloma Navarro, Verónica García Navas, Arántzazu Barquín García, Elena Sevillano Fernández, Sergio Ruiz Llorente, Juan Francisco Rodriguez, Monica Yagüe, Joan Ballesteros, Daniel Primo, Jesus Garcia Donas Jimenez   +10 more
doaj   +1 more source

Muscle-clipping suturing for closure of a gastric defect after endoscopic submucosal dissection for a type 3 neuroendocrine neoplasm. [PDF]

Endoscopy
Ramos-Zabala F, Alzina-Pérez A, Mejía E, García-Mayor M, Díaz-Molina RJ, Moreno-Almazán L.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

[Unequal impact of COVID-19 on mortality in long-term care homes across health areas of Castilla-La Mancha (Spain)]. [PDF]

An Sist Sanit Navar
Zunzunegui Pastor MV, Rubio Mengual I, Villar Baile Á, García López FJ.   +3 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source