Results 121 to 130 of about 270,120 (271)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Gestación en tiempos de pandemia COVID-19 en un hospital peruano: Comentarios a un artículo

Revista Internacional de Salud Materno Fetal
El artículo “Riesgo obstétrico y salud neonatal en tiempos de pandemia por Sars CoV 2 (Covid 19)” presenta aportes relevantes en contexto local, pero adolece de importantes limitaciones metodológicas y analíticas.
Alexander Ramos-Cchencho, Javier Mendoza-Quispe   +1 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Sistema de salud y utilización hospitalaria en Chile, 1952–2020: tendencias, reformas y puntos de inflexión

Revista Panamericana de Salud Pública
Objetivo. El objetivo de este trabajo fue recabar y analizar la evolución de los egresos hospitalarios en Chile entre 1952 y el 2020, tanto a nivel nacional como en el subsistema público.
Mauricio Matus-López
doaj   +1 more source

Diseño y construcción del Hospital Infanta Leonor en Vallecas (Madrid) = Design and construction of the Infanta Leonor Hospital. Vallecas (Madrid) [PDF]

, 2010
El Hospital Infanta Leonor en Vallecas se ha planteado como una investigación sobre la nueva generación de hospitales flexibles, basada en los sistemas constructivos, buscando un diseño innovador como alternativa a los esquemas hospitalarios ...
Araujo Armero, Ramón
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

npj Parkinson's Disease
Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson’s disease (PD), while those in the dorsal tier and ventral tegmental area are relatively spared.
Tiziano Balzano, Natalia López-González del Rey, Noelia Esteban-García, Alejandro Reinares-Sebastián, José A. Pineda-Pardo, Inés Trigo-Damas, José A. Obeso, Javier Blesa   +7 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Acreditación de Hospitales

, 1996
Hospital accreditation is one of the most important actions to guarantee quality in health services. Although in other countries hospital accreditation has being carried out for four decades, in Latin American countries it was introduced as a systematized process just at the beginning of this decade. In order to get a greater approval by accreditation,
Santacruz Varela, Javier, Instituto Peruano de Seguridad Social   +1 more
openaire   +1 more source