Results 171 to 180 of about 5,109,898 (358)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
, 1996 Hospital accreditation is one of the most important actions to guarantee quality in health services. Although in other countries hospital accreditation has being carried out for four decades, in Latin American countries it was introduced as a systematized process just at the beginning of this decade. In order to get a greater approval by accreditation,
Santacruz Varela, Javier +1 more
openaire +1 more source
National Hospital Discharge Survey, 1975
, 1975 United States Department of Health and Human Services. National Center for Health Statistics
openalex +1 more source
Prevalence and Risk Factors of Undernutrition among Infants Less Than Six Months: A Hospital Based Cross-Sectional Assessment [PDF]
, 2023 Priyanka Verma +7 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Causes of pediatric mortality and case-fatality rates in eight Médecins Sans Frontières-supported hospitals in Africa [PDF]
, 2012 Harries, A D +3 more
core +2 more sources