Results 111 to 120 of about 778,069 (297)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
University Hospitals General Staff Meeting, June 4, 1931
, 1931 University of Minnesota. University of Minnesota Hospitals. (1931). University Hospitals General Staff Meeting, June 4, 1931.
University of Minnesota. University of Minnesota Hospitals
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FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
University Hospitals General Staff Meeting, January 8, 1931
, 1931 University of Minnesota. University of Minnesota Hospitals. (1931). University Hospitals General Staff Meeting, January 8, 1931.
University of Minnesota. University of Minnesota Hospitals
core
Training the trainees in robotic surgery – a pilot scheme in the United Kingdom
BMC Medical EducationBackground Training in robotic colorectal surgery is predominantly confined to senior trainees and consultants. The lack of robotic training of the general surgical specialist trainee (ST) in the formative stages of training has led to widespread ...
Mohammed Al-Ani +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
University Hospitals General Staff Meeting, October 27, 1932
, 1932 University of Minnesota. University of Minnesota Hospitals. (1932). University Hospitals General Staff Meeting, October 27, 1932.
University of Minnesota. University of Minnesota Hospitals
core
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
University Hospitals General Staff Meeting, April 13, 1933
, 1933 University of Minnesota. University of Minnesota Hospitals. (1933). University Hospitals General Staff Meeting, April 13, 1933.
University of Minnesota. University of Minnesota Hospitals
core