Results 41 to 50 of about 18,891 (267)

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

The digital divide among U.S. Hospitals delivering health services to populations with high social disparities

Frontiers in Digital Health
ObjectiveThe objective of this research is to examine the relationship between digital maturity and hospital care provided to patients who are living with high social disparities.Materials and methodsThis cross-sectional observational study used digital ...
Anne Snowdon, Abdulkadir Hussein, Alexandra Wright, Tim Storey, Kristin Pratico, Reid Oakes   +5 more
doaj   +1 more source

Prediction of Long‐Term Prognosis in Patients With Hepatocellular Carcinoma Using the National Clinical Database Risk Calculator

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to determine the value of the National Clinical Database (NCD) risk calculator in predicting surgical outcomes and long‐term prognosis in patients undergoing resection for hepatocellular carcinoma (HCC). We retrospectively analyzed data from 210 patients with HCC who underwent initial hepatic resection, assessing the relationship ...
Mariko Tsukagoshi, Kenichiro Araki, Norio Kubo, Takamichi Igarashi, Shunsuke Kawai, Kei Hagiwara, Kouki Hoshino, Ryo Muranushi, Ken Shirabe   +8 more
wiley   +1 more source

Alguns dados sobre a participação do Engenheiro Samuel das Neves no plano de melhoramentos de São Paulo

Pós: Revista do Programa de Pós-Graduação em Arquitetura e Urbanismo da FAUUSP, 1996
Some data on the participation of the engineer Samuel das Neves in Sâo Paulo's Improvements Plan. One of the outstanding professionals in São Paulo during the turn of the century was Bahia's agronomistengineer Samuel das Neves.
Maria Ruth Amaral de Sampaio
doaj  

Hospital‐ and county‐level characteristics explain geographic variability in prices of cancer‐related procedures: Implications for policy and interventions

Cancer Medicine
Background Healthcare costs in the U.S. are high and variable, which can hinder access and impact health outcomes across communities. This study examined hospital‐ and county‐level characteristics to identify factors that explain geographic variation in ...
Jennifer L. Moss, Savanna G. Ledford, Veronica Bernacchi, Chan Shen   +3 more
doaj   +1 more source

High Diagnosis Rate for Nonimmune Hydrops Fetalis With Prenatal Clinical Genome: Expanded Results From the Hydrops‐Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Nonimmune hydrops fetalis (NIHF) is characterized by abnormal fluid accumulation in ≥ 2 fetal compartments and may be genetic. The incremental diagnostic yield of prenatal exome sequencing (ES) for NIHF following a negative standard workup was previously explored on 22 cases.
Stephanie M. Rice, Mona M. Makhamreh, Sascha Wodoslawsky, Mariella Toro, Elizabeth Critchlow, Brandy Firman, Ruby Liu, Babi Ramesh Nallamilli, Madhuri Hegde, Seth I. Berger, Huda B. Al‐Kouatly   +10 more
wiley   +1 more source

Increased consumption of cardiovascular drugs under volume-based procurement (VBP) policy: demand release or assessment inducing?

Health Research Policy and Systems
Background The phenomenon of growth in drug consumption within the framework of national volume-based procurement (VBP) policy raises speculations about demand release and policy inducing.
Ying Yang, Jieming Zhang, Yuanhui Duan, Lei Zhou, Sisheng Gan, Zongfu Mao, Shaotang Wu, Furong Wang   +7 more
doaj   +1 more source

Evaluating a Widely Implemented Proprietary Deterioration Index Model Among Hospitalized COVID-19 Patients [PDF]

, 2020
ABSTRACT Introduction The Epic Deterioration Index (EDI) is a proprietary prediction model implemented in over 100 U.S. hospitals that was widely used to support medical decision-making during the COVID-19 pandemic.
Karandeep Singh, Thomas S. Valley, Shengpu Tang, Benjamin Y. Li, Fahad Kamran, Michael W. Sjoding, Jenna Wiens, Erkin Otles, John P. Donnelly, Melissa Y. Wei, Jonathon P. McBride, Jie Cao, Carleen Penoza, John Z. Ayanian, Brahmajee K. Nallamothu   +14 more
openaire   +2 more sources

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source