Results 41 to 50 of about 18,956 (305)

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

Advanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma, Pengcheng Yao, Shengqi Wu, Yuanyuan Shi, Lang Qin, Baitao Li, Jiayi Zhu, Minhua Huang, Yichong Zhu, Yuwen Song, Jinhuan Pang, Ziping Guo, Guochuan Wu, Chen Wang, Kewei Xu, Ruihua Huang, Quan Kuang, Liang Qu, Changtian Pan, Xianrong Xie, Qinlong Zhu, Jiaying Huang, Qiupeng Lin   +22 more
wiley   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Understanding the Security and Performance of the Web Presence of Hospitals: A Measurement Study

, 2023
Using a total of 4,774 hospitals categorized as government, non-profit, and proprietary hospitals, this study provides the first measurement-based analysis of hospitals' websites and connects the findings with data breaches through a correlation analysis.
Nyang, DaeHun, Alabduljabbar, Abdulrahman, Althebeiti, Hattan, Jang, Rhongho, Alkinoon, Mohammed, Mohaisen, David   +5 more
core  

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

An Analysis of Patient Satisfaction in Religiously-affiliated Versus Non-Religiously-affiliated Hospitals.

, 2023
Despite a decline in funding there has been an increase in the percentage of hospitals with religious affiliation in the United States. However, there have been no studies to investigate the relationship between religious affiliation and patient ...
Tanner, Afton.
core  

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

[[alternative]]Relationship between Board Characteristics and Healthcare Quality for Non-Profit Proprietary Hospitals in Taiwan

, 2020
[[abstract]]背景：隨著健保制度不斷變革，醫療院所面臨巨大的財務壓力，使得醫院經營不易而逐年減少，因應醫療環境衝擊各醫院採取相對應的措施以維持正常營運，但為了減少虧損及降低醫療成本，醫療品質往往被忽略，使得財團法人醫院重視營利績效而模糊其公益性之角色，因此董事會監督及治理逐漸受到重視。目的：探討財團法人醫院董事會結構及成員特性與醫療品質之關係。方法：本研究資料來源為衛生福利部提供的醫院總額指標及醫事司的財務報表，研究期間為2012-2017年，共32間財團法人醫院；自變項為董事會成員背景及特性，
Chi, Chia-Yu, 紀佳妤
core  

Alguns dados sobre a participação do Engenheiro Samuel das Neves no plano de melhoramentos de São Paulo

Pós: Revista do Programa de Pós-Graduação em Arquitetura e Urbanismo da FAUUSP, 1996
Some data on the participation of the engineer Samuel das Neves in Sâo Paulo's Improvements Plan. One of the outstanding professionals in São Paulo during the turn of the century was Bahia's agronomistengineer Samuel das Neves.
Maria Ruth Amaral de Sampaio
doaj  

Hospital‐ and county‐level characteristics explain geographic variability in prices of cancer‐related procedures: Implications for policy and interventions

Cancer Medicine
Background Healthcare costs in the U.S. are high and variable, which can hinder access and impact health outcomes across communities. This study examined hospital‐ and county‐level characteristics to identify factors that explain geographic variation in ...
Jennifer L. Moss, Savanna G. Ledford, Veronica Bernacchi, Chan Shen   +3 more
doaj   +1 more source