Results 51 to 60 of about 65,280 (309)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Hospital‐ and county‐level characteristics explain geographic variability in prices of cancer‐related procedures: Implications for policy and interventions

Cancer Medicine
Background Healthcare costs in the U.S. are high and variable, which can hinder access and impact health outcomes across communities. This study examined hospital‐ and county‐level characteristics to identify factors that explain geographic variation in ...
Jennifer L. Moss, Savanna G. Ledford, Veronica Bernacchi, Chan Shen   +3 more
doaj   +1 more source

Risk Factors for Hospital Malpractice Exposure: Implications for Managers and Insurers [PDF]

, 1991
The possibility of identifying certain variables that might serve as predictors of above- or below-average medical malpractice claims experience was explored.
Katz, Patricia P., Luft, Harold S., Pinney, Douglas G.   +2 more
core   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Alguns dados sobre a participação do Engenheiro Samuel das Neves no plano de melhoramentos de São Paulo

Pós: Revista do Programa de Pós-Graduação em Arquitetura e Urbanismo da FAUUSP, 1996
Some data on the participation of the engineer Samuel das Neves in Sâo Paulo's Improvements Plan. One of the outstanding professionals in São Paulo during the turn of the century was Bahia's agronomistengineer Samuel das Neves.
Maria Ruth Amaral de Sampaio
doaj  

Increased consumption of cardiovascular drugs under volume-based procurement (VBP) policy: demand release or assessment inducing?

Health Research Policy and Systems
Background The phenomenon of growth in drug consumption within the framework of national volume-based procurement (VBP) policy raises speculations about demand release and policy inducing.
Ying Yang, Jieming Zhang, Yuanhui Duan, Lei Zhou, Sisheng Gan, Zongfu Mao, Shaotang Wu, Furong Wang   +7 more
doaj   +1 more source

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Circular Economy in the Healthcare Industry: Developing a Circularity Assessment Tool for Complex Medical Devices

Business Strategy and the Environment, EarlyView.
ABSTRACT As the circular economy transition gains traction in the healthcare sector, extending the lifespan of complex medical devices has become a key priority, given their high cost and the challenges associated with their technological sophistication.
Tetiana Shevchenko, Lauren Durivault, Meisam Ranjbari, Zahra Shams Esfandabadi, Bernard Yannou, Robert Heidsieck, Michael Saidani, Ghada Bouillass   +7 more
wiley   +1 more source

Evaluating a Widely Implemented Proprietary Deterioration Index Model Among Hospitalized COVID-19 Patients [PDF]

, 2020
ABSTRACT Introduction The Epic Deterioration Index (EDI) is a proprietary prediction model implemented in over 100 U.S. hospitals that was widely used to support medical decision-making during the COVID-19 pandemic.
Karandeep Singh, Thomas S. Valley, Shengpu Tang, Benjamin Y. Li, Fahad Kamran, Michael W. Sjoding, Jenna Wiens, Erkin Otles, John P. Donnelly, Melissa Y. Wei, Jonathon P. McBride, Jie Cao, Carleen Penoza, John Z. Ayanian, Brahmajee K. Nallamothu   +14 more
openaire   +2 more sources

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source