Results 91 to 100 of about 1,278,838 (309)

Overcoming the Challenges to Primary Healthcare and Universal Health Coverage in Nigeria: The Pivotal Role of the Family Physician

Nigerian Frontline Medicine Journal
BackgroundNigeria, the most populous country in Africa and the leading nation in sub-Saharan Africa, is facing a severe healthcare crisis. Its life expectancy of 62.2 years and other worsening health indicators, such as a maternal mortality rate of 814 ...
Ibrahim S. Bello, Abdulakeem A. Ahmed, Blessing T. Olaniyi, Fatai A. Olaniyan, Omowonuola O. Sonibare   +4 more
doaj  

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Assessment of epidemic risk state and its change trend of public hospital in underdeveloped area in different stages

Frontiers in Public Health
ObjectiveEpidemics are sudden and rapidly spreading. Hospitals in underdeveloped areas are particularly vulnerable in case of an outbreak. This paper aims to assess the epidemic risk state and its change trend of hospitals in different epidemic stages ...
Ming Yang, Ming Yang, Jingjing Miao, Tiebing Li, Rong Jiang, Rong Jiang, Min Jiang   +6 more
doaj   +1 more source

Detecting Medicare Abuse [PDF]

This paper identifies which types of patients and hospitals have abusive Medicare billings that are responsive to law enforcement. For a 20 percent random sample of elderly Medicare beneficiaries hospitalized from 1994-98 with one or more of six ...
Daniel Kessler, David Becker, Mark McClellan   +2 more
core  

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Atherogenic Index of Plasma and its Relationship with Cardiovascular Risk Factors Among Adult Patients Attending a Primary Care Clinic in South West Nigeria

Nigerian Frontline Medicine Journal
Background: Cardiovascular diseases have remained major causes of death globally. Early identification of individuals at risk of cardiovascular disease and appropriate intervention is needed in order to reduce the disease burden.
Adeyinka O. Ilesanmi, Ibrahim S. Bello, Akinjide O. Ogundokun, Oluwafemi T. Ile, Azeez O. Ibrahim, Samuel A. Olowookere   +5 more
doaj  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

Treatment of an Opposing Metabolic Situation: GLUT1‐Deficiency Syndrome and Type 1 Diabetes

JIMD Reports
Glucose transporter type 1 deficiency syndrome (GLUT1‐DS) is a rare inborn disorder of metabolism leading to encephalopathy due to disturbed glucose transport via the blood–brain‐barrier and consecutive energy deficit of the brain.
Anna K. Schoenlaub, Alexander Hoeller, Sabine Hofer, Edda Haberlandt, Elisabeth Steichen‐Gersdorf, Daniela Karall, Dorottya Forster, Sabine Scholl‐Bürgi   +7 more
doaj   +1 more source