Results 161 to 170 of about 13,356,795 (360)

A Susceptible-Exposed-Infected-Removed (Seir) Model For The 2009-2010 A/H1N1 Epidemic In Istanbul [PDF]

arXiv, 2012
A/H1N1 epidemic data from Istanbul, Turkey during the period June 2009-February 2010 is analyzed with SEIR (Susceptible-Exposed-Infected-Removed) model. The data consist of the daily adult hospitalization numbers and fatalities recorded in various state hospitals serving an adult population of about 1.5-2 million.
arxiv  

Detecting Medicare Abuse [PDF]

This paper identifies which types of patients and hospitals have abusive Medicare billings that are responsive to law enforcement. For a 20 percent random sample of elderly Medicare beneficiaries hospitalized from 1994-98 with one or more of six ...
Daniel Kessler, David Becker, Mark McClellan   +2 more
core  

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

The Economic Impact of North Dakota's Health Care Industry on the State's Economy in 1991 [PDF]

The health care industry's far-reaching economic influence within North Dakota is the focus of this report. An input-output model is used to estimate the economic impact of hospitals and long-term care nursing facilities. The analysis shows that nearly 8
Coon, Randal C., Hamm, Rita R., Leistritz, F. Larry, Thompson, JoAnn M.   +3 more
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Antibiotic use in different hospital administrative categories: an overview of 10 years of a statewide surveillance program in Brazil

Antimicrobial Stewardship & Healthcare Epidemiology
Objective: The present study aimed to describe ICU antibiotic use based on data reported from 2009 to 2018 to the Nosocomial Surveillance System (NSS) of the State Health Department in the State of Sao Paulo, Brazil. Design: Ecological study. Setting:
Filipe Piastrelli, Denise Brandão de Assis, Geraldine Madalosso, Ícaro Boszczowski   +3 more
doaj   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Evaluation of ergonomics awareness and its lack of application on medical laboratory practitioners in tertiary hospitals in Jos, Plateau, Nigeria

International Journal of Medicine and Health Development
Background: The study of how people interact with their work environment is known as ergonomics. Medical laboratory practitioners are exposed to work-related musculoskeletal disorders, resulting in a reduction in the quality of health care services ...
Bamidele O Olumide, Nimnan F Tyem, Bala D Ntuhun, Mercy E Ekpenyong, Seth T Ariyo, Temitope T Selowo, Nanpyal B Longs, Steve K Oyero, Emmanuel B Longkem, Yakubu B Fiyaktu   +9 more
doaj   +1 more source