Results 141 to 150 of about 6,237,452 (333)

EIF5A Couples Translational Control With Transcriptional Reprogramming Through Chromocenter Reorganization During Spermiogenesis

Advanced Science, EarlyView.
The translation factor Eukaryotic translation initiation factor 5A (eIF5A) is essential for male fertility in mice. It supports the translation of proteins crucial for heterochromatin organization and acrosome formation. eIF5A deficiency disrupts chromocenter integrity, increases chromatin accessibility, and causes transcriptional dysregulation ...
Yuling Cai, Tongtong Li, Qian Fang, Ziyou Bao, Feng Kong, Huitao Qi, Hanzhen Li, Mingyu Zhang, Wei Wang, Yongxia Guan, Wenbo Liu, Xiangfeng Chen, Zi‐Jiang Chen, Xiaohua Jiang, Xin Wang, Hongbin Liu   +15 more
wiley   +1 more source

Patient Outcomes Following Infected Femoral Artery Pseudoaneurysms in Intravenous Drug Users: A Single Centre Four Year Cohort Study

EJVES Vascular Forum, 2022
Ryan Laloo, Max Troxler, Tim Stansfield, David Julian Ashbridge Scott   +3 more
doaj   +1 more source

Inpatient morbidity and mortality after adult spinal deformity surgery in teaching versus nonteaching hospitals.

Journal of Neurosurgery : Spine, 2016
Rafael De la Garza-Ramos, Amit Jain, K. Kebaish, A. Bydon, P. Passias, D. Sciubba   +5 more
semanticscholar   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

A Biomimetic Norepinephrine‐Loaded Aligned Mineralized Collagen Scaffold for Coordinated Neurovascular, Osteogenic, and Immunomodulatory Repair of Critical‐Sized Bone Defects

Advanced Science, EarlyView.
Inspired by the composition and structure of native bone tissue and its complex interplay of biological signals, a norepinephrine‐loaded biomimetic mineralized electrocompacted collagen scaffold (NE‐MEC) is developed capable of simultaneously supporting osteogenesis, neural repair, angiogenesis, and immune modulation.
Zhengyun Ren, Zhaojun Wu, Anhang Wu, Hui Zhang, Jiachen Lu, Jiahao Zhang, Jie Weng, Jinhua Zhang, Song Chen, Huan Tan, Tailin Guo   +10 more
wiley   +1 more source

Transcatheter Treatment of Superior Sinus Venosus Atrial Septal Defect (SVASD) with Partial Anomalous Pulmonary Venous Drainage (PAPVD): The Critical Role of 3D Modelling

Journal of Cardiovascular Magnetic Resonance
Karina Gopaul, MRCP, BSc, MB, Lisa Ferrie, MSc, BSc, Julian Tonge, Stephen Mhiribidi, James Bentham, Kate English, Vitor Ramos, MD   +6 more
doaj   +1 more source

Healthcare and Teaching Hospitals [PDF]

Revista da Associação Médica Brasileira, 2018
Olímpio J. Nogueira V. Bittar, José Dínio Vaz Mendes   +1 more
openaire   +2 more sources

Piezo‐Phototronic PVDF/HfO2/Nano‐Cu Heterostructured Thin Film for Flexible Self‐Powered Multimodal Sensing

Advanced Science, EarlyView.
Electrospinning a composite of PVDF, HfO2, and nano‐Cu transforms the discrete precursors into a continuous nanofiber mesh, forming a multi‐interface heterostructure with embedded nanoparticles. The presence of HfO2 and nano‐Cu at the fiber interfaces induces a highly aligned β‐phase, which enhances piezoelectric crystallinity and improves the material'
Jiawei Gu, Qiongle Peng, Xuanqi Zhong, Yi Zheng, Zhiqiang Ma, Xiaoxian Song, Ruihuan Zhang, Bao Liu, Yanhu Zhang, Zhengbao Yang   +9 more
wiley   +1 more source

Evaluating artificial intelligence for lung cancer detection on chest radiographs: multi-vendor comparison in a retrospective real-world UK population

The Royal College of Radiologists Open
Ahmed Maiter, Peter Metherall, Jonathan Taylor, Suzanne Matthews, Emily Burton, Katherine Hocking, Sean Burns, Hannah Reilly, Elizabeth Anderson, Samer Alabed, Krit Dwivedi, Mohammed Kamil, Oscar Evans, Wendy Tindale, Andrew Swift, Christopher Johns   +15 more
doaj   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source