Results 21 to 30 of about 605,263 (307)

Evaluation of some spiral and sequential computed tomography protocols of adults used in three hospitals in Shiraz, Iran with American College of Radiology and European Commission guidelines [PDF]

, 2018
Purpose: Use of computed tomography (CT) has increased considerably all over the world. In addition, there has been an increased demand for utilisation of CT scanning in Iran over the past decade, especially after introducing multi-detector computed ...
Eghlidospoor, Mahdavi, Maziyar, Rahimi, Saeed   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The Problem with Big Data: Operating on Smaller Datasets to Bridge the Implementation Gap

Frontiers in Public Health, 2016
Big datasets have the potential to revolutionize public health. However, there is a mismatch between the political and scientific optimism surrounding big data and the public’s perception of its benefit.
Richard Mann, Faisal Mushtaq, Alan White, Gabriel Cervantes, Tom Pike, Tom Pike, Dalton Coker, Stuart Murdoch, Tim Hiles, Clare Smith, David Berridge, Geoff Hall, Suzanne Hinchliffe, Stephen Smye, Stephen Smye, Richard McGilchrist Wilkie, Peter Lodge, Peter Lodge, Mark Mon-Williams   +18 more
doaj   +1 more source

C1 inhibitor deficiency: 2014 United Kingdom consensus document [PDF]

, 2015
C1 inhibitor deficiency is a rare disorder manifesting with recurrent attacks of disabling and potentially life-threatening angioedema. Here we present an updated 2014 United Kingdom consensus document for the management of C1 inhibitor-deficient ...
Ashworth, F, Bethune, C, Cale, C, Dempster, J, Edgar, D, Gompels, M, Jolles, S, Longhurst, H J, Price, A, Seneviratne, S, Symons, C, Tarzi, M D   +11 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Identifying gaps and optimising clinical practice and guideline of adrenal incidentaloma management

Clinical Medicine
Background: Adrenal incidentalomas are adrenal masses discovered incidentally during imaging performed for unrelated medical reasons. Their management requires a systematic approach to exclude malignancy and hormonal hypersecretion while ensuring ...
Chan Khin, Samriaz Nafees, Muhammad Haroon Riasat, Riya Raphael, Mojeed Adiat, Nicholas Mcwhirter, Fatima Ali   +6 more
doaj   +1 more source

Privatisation of teaching hospitals [PDF]

Medical Journal of Australia, 1999
Australia's major academic health centres not only provide excellent healthcare, but are also involved in one of the most important aspects of the healthcare system - the training of our future health professionals. Most teaching hospitals are also involved in basic and clinical research, and many have major research institutes on their campuses.
openaire   +2 more sources

The Catholic Doctor, the Catholic Hospital and Contraception [PDF]

, 1973
In the following article, he reviews the position of the Catholic Church on contraception . After affirming the Pope\u27s supreme teaching authority, he outlines the papal attitude toward contraception and stresses the objective evil of artificial birth ...
Harrington, Paul V.
core   +1 more source