Results 51 to 60 of about 150,290 (299)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +1 more source

Chlamydia trachomatis Inclusion Membrane Protein CT228 Recruits Elements of the Myosin Phosphatase Pathway to Regulate Release Mechanisms

Cell Reports, 2013
Chlamydia trachomatis replicates within a membrane-bound compartment termed an inclusion. The inclusion membrane is modified by the insertion of multiple proteins known as Incs. In a yeast two-hybrid screen, an interaction was found between the inclusion
Erika I. Lutter, Alexandra C. Barger, Vinod Nair, Ted Hackstadt   +3 more
doaj   +1 more source

Parallelism and divergence in immune responses: a comparison of expression levels in two lakes [PDF]

, 2014
Question: How do immune phenotypes differ between infected and uninfected wild individuals, and is the effect the same in different populations? Organisms: Threespine stickleback (Gasterosteus aculeatus) from two lake populations on the island of North ...
Ando, Ando, Anquetin, Anquetin, Baba, Bass, Berx, Berx, Berx, Birchmeier, Bracke, Brown, Chen, Christofori, Cukierman, David, Dias, Efstathiou, Gaul, Gaul, Gottlieb, Hedley, Ju, Lecomte, Machado, Maddess, Majchrzak, Morton, Morton, Munro, Nobis, Oskarsson, Reymond, Reymond, Risinger, Serrels, Shan, Sprague, Thiery, Timpson, Timpson, Trost, Umbas, Zhou   +43 more
core   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

Extracellular Vesicles Mediate Epimastigogenesis in Trypanosoma cruzi: Strain-Specific Dynamics and Temperature-Dependent Differentiation

Life
Trypanosoma cruzi, the causative agent of Chagas disease, undergoes epimastigogenesis—a critical differentiation step in which trypomastigotes transform into epimastigotes. While this process is essential for the parasite’s survival in its insect vector,
Abel Sana, Izadora Volpato Rossi, Bruna Sabatke, Marcel Ivan Ramirez   +3 more
doaj   +1 more source

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

eLife, 2018
The intracellular parasite Toxoplasma gondii, hijacks evolutionarily conserved host processes by delivering effector proteins into the host cell that shift gene expression in a timely fashion.
Huan He, Marie-Pierre Brenier-Pinchart, Laurence Braun, Alexandra Kraut, Bastien Touquet, Yohann Couté, Isabelle Tardieux, Mohamed-Ali Hakimi, Alexandre Bougdour   +8 more
doaj   +1 more source

Composites of Shellac and Silver Nanowires as Flexible, Biobased, and Corrosion‐Resistant Transparent Conductive Electrodes

Advanced Functional Materials, EarlyView.
Shellac, a centuries‐old natural resin, is reimagined as a green material for flexible electronics. When combined with silver nanowires, shellac films deliver transparency, conductivity, and stability against humidity. These results position shellac as a sustainable alternative to synthetic polymers for transparent conductors in next‐generation ...
Rahaf Nafez Hussein, Tiago Carneiro Gomes, Eliza Ng, Simon Rondeau‐Gagné, Tricia Breen Carmichael   +4 more
wiley   +1 more source

Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia

Cell Reports, 2016
Participation of B cells in the immune response by various antibody-independent mechanisms has recently been uncovered. B cells producing cytokines have been described for several infections and appear to regulate the adaptive immune response.
Sasha Silva-Barrios, Mélina Smans, Claudia U. Duerr, Salman T. Qureshi, Jörg H. Fritz, Albert Descoteaux, Simona Stäger   +6 more
doaj   +1 more source