Results 41 to 50 of about 3,982,340 (252)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

BMC Biology, 2021
Background Biomarker discovery remains a major challenge for predictive medicine, in particular, in the context of chronic diseases. This is true for the widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism in metazoans ...
Céline Dard, Christopher Swale, Marie-Pierre Brenier-Pinchart, Dayana C. Farhat, Valeria Bellini, Marie Gladys Robert, Dominique Cannella, Hervé Pelloux, Isabelle Tardieux, Mohamed-Ali Hakimi   +9 more
doaj   +1 more source

Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against Plasmodium

Frontiers in Immunology, 2022
Malaria is a major public health concern, as a highly effective human vaccine remains elusive. The efficacy of a subunit vaccine targeting the most abundant protein of the sporozoite surface, the circumsporozoite protein (CSP) has been hindered by ...
Ana Rafaela Teixeira, Ana Rafaela Teixeira, Ana Rafaela Teixeira, Begoña Pérez-Cabezas, Begoña Pérez-Cabezas, David M. Costa, David M. Costa, Mónica Sá, Mónica Sá, Mónica Sá, Sylvain Golba, Hélèna Sefiane-Djemaoune, Joana Ribeiro, Joana Ribeiro, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Rogerio Amino, Anabela Cordeiro-da-Silva, Anabela Cordeiro-da-Silva, Anabela Cordeiro-da-Silva, Joana Tavares, Joana Tavares, Joana Tavares   +26 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Metazoan-protozoan parasite co-infections and host body weight in St Kilda Soay sheep [PDF]

, 2008
For hundreds of years, the unmanaged Soay sheep population on St Kilda has survived despite enduring presumably deleterious co-infections of helminth, protozoan and arthropod parasites and intermittent periods of starvation.
Tempest, L. J., Pilkington, J. G., Pemberton, J. M., Craig, B. H.   +3 more
core   +1 more source

Regulation and Roles of Metacyclogenesis and Epimastigogenesis in the Life Cycle of Trypanosoma cruzi

Pathogens
Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits remarkable developmental plasticity that enables its survival across distinct environments within the insect vector and mammalian host.
Abel Sana, Izadora Volpato Rossi, Marcel Ivan Ramirez   +2 more
doaj   +1 more source

Chlamydia trachomatis Inclusion Membrane Protein CT228 Recruits Elements of the Myosin Phosphatase Pathway to Regulate Release Mechanisms

Cell Reports, 2013
Chlamydia trachomatis replicates within a membrane-bound compartment termed an inclusion. The inclusion membrane is modified by the insertion of multiple proteins known as Incs. In a yeast two-hybrid screen, an interaction was found between the inclusion
Erika I. Lutter, Alexandra C. Barger, Vinod Nair, Ted Hackstadt   +3 more
doaj   +1 more source

Systems analysis of host–parasite interactions [PDF]

WIREs Systems Biology and Medicine, 2015
Parasitic diseases caused by protozoan pathogens lead to hundreds of thousands of deaths per year in addition to substantial suffering and socioeconomic decline for millions of people worldwide. The lack of effective vaccines coupled with the widespread emergence of drug‐resistant parasites necessitates that the research community take an active role ...
Swann, Justine, Jamshidi, Neema, Lewis, Nathan E, Winzeler, Elizabeth A   +3 more
openaire   +4 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Role for parasite genetic diversity in differential host responses to Trypanosoma brucei infection [PDF]

, 2010
The postgenomic era has revolutionized approaches to defining host-pathogen interactions and the investigation of the influence of genetic variation in either protagonist upon infection outcome.
C. Michael R. Turner, Chan, Chi N, Tait, Andy, Andy Tait, Morrison, L.J., McLellan, Sarah, Turner, C Michael R, Sweeney, Lindsay, Chan, C.N., Liam J. Morrison, Annette MacLeod, Sweeney, L., Turner, C.M.R., Morrison, Liam J; id_orcid, Lindsay Sweeney, Chi N. Chan, Tait, A., Sarah McLellan, MacLeod, A., McLellan, S., MacLeod, Annette   +20 more
core   +1 more source