Results 21 to 30 of about 62,021 (264)

Targeted Knockout of the Rickettsia rickettsii OmpA Surface Antigen Does Not Diminish Virulence in a Mammalian Model System

mBio, 2015
Strains of Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever (RMSF), differ dramatically in virulence despite >99% genetic homology.
Nicholas F. Noriea, Tina R. Clark, Ted Hackstadt   +2 more
doaj   +1 more source

Promise and limitations of 18S genetic screening of extracted fecal DNA from wild capuchins

Frontiers in Ecology and Evolution, 2023
Genomic screening of fecal DNA provides insight into diet, parasite infection dynamics, and other aspects of the ecology and pathogens of wild populations.
Swellan Luciann Pinto, Swellan Luciann Pinto, Megan Carvalho Henriquez, Megan Carvalho Henriquez, Megan Carvalho Henriquez, Megan Carvalho Henriquez, Saul Cheves Hernandez, Gwen Duytschaever, Janneke Wit, Janneke Wit, Russell William Avramenko, Russell William Avramenko, John Stuart Gilleard, John Stuart Gilleard, Joseph Daniel Orkin, Joseph Daniel Orkin, Amanda Dawn Melin, Amanda Dawn Melin, Amanda Dawn Melin, Amanda Dawn Melin   +19 more
doaj   +1 more source

Discovery of RUF6 ncRNA–interacting proteins involved in P. falciparum immune evasion

Life Science Alliance, 2023
An RNA-directed proteomic discovery (ChIRP-MS) protocol is used to identify in vivo RUF6 ncRNA–protein interactions that sustain virulence genes in the human malaria parasite, Plasmodium falciparum .
Gretchen M Diffendall, Anna Barcons-Simon, Sebastian Baumgarten, Florent Dingli, Damarys Loew, Artur Scherf   +5 more
doaj   +1 more source

The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum

mBio, 2018
Strains of Rickettsia rickettsii, the tick-borne agent of Rocky Mountain spotted fever, vary considerably in virulence. Genomic comparisons of R. rickettsii strains have identified a relatively small number of genes divergent in an avirulent strain ...
Stephanie S. Lehman, Nicholas F. Noriea, Karin Aistleitner, Tina R. Clark, Cheryl A. Dooley, Vinod Nair, Simran Jeet Kaur, M. Sayeedur Rahman, Joseph J. Gillespie, Abdu F. Azad, Ted Hackstadt   +10 more
doaj   +1 more source

Functional Characterization of the m ⁶ A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite

mBio, 2021
Infection with the unicellular eukaryotic pathogen Plasmodium ...
Ameya Sinha, Sebastian Baumgarten, Amy Distiller, Emma McHugh, Patty Chen, Meetali Singh, Jessica M. Bryant, Jiaqi Liang, Germano Cecere, Peter C. Dedon, Peter R. Preiser, Stuart A. Ralph, Artur Scherf   +12 more
doaj   +1 more source

Profiling the macrofilaricidal effects of flubendazole on adult female Brugia malayi using RNAseq

International Journal for Parasitology: Drugs and Drug Resistance, 2016
The use of microfilaricidal drugs for the control of onchocerciasis and lymphatic filariasis (LF) necessitates prolonged yearly dosing. Prospects for elimination or eradication of these diseases would be enhanced by the availability of a macrofilaricidal
Maeghan O'Neill, Cristina Ballesteros, Lucienne Tritten, Erica Burkman, Weam I. Zaky, Jianguo Xia, Andrew Moorhead, Steven A. Williams, Timothy G. Geary   +8 more
doaj   +1 more source

Current Treatments to Control African Trypanosomiasis and One Health Perspective

Microorganisms, 2022
Human African Trypanosomiasis (HAT, sleeping sickness) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases generally caused by the same etiological agent, Trypanosoma brucei.
Alberto Venturelli, Lorenzo Tagliazucchi, Clara Lima, Federica Venuti, Giulia Malpezzi, George E. Magoulas, Nuno Santarem, Theodora Calogeropoulou, Anabela Cordeiro-da-Silva, Maria Paola Costi   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

BMC Biology, 2021
Background Biomarker discovery remains a major challenge for predictive medicine, in particular, in the context of chronic diseases. This is true for the widespread protozoan Toxoplasma gondii which establishes long-lasting parasitism in metazoans ...
Céline Dard, Christopher Swale, Marie-Pierre Brenier-Pinchart, Dayana C. Farhat, Valeria Bellini, Marie Gladys Robert, Dominique Cannella, Hervé Pelloux, Isabelle Tardieux, Mohamed-Ali Hakimi   +9 more
doaj   +1 more source

Immunization with CSP and a RIG-I Agonist is Effective in Inducing a Functional and Protective Humoral Response Against Plasmodium

Frontiers in Immunology, 2022
Malaria is a major public health concern, as a highly effective human vaccine remains elusive. The efficacy of a subunit vaccine targeting the most abundant protein of the sporozoite surface, the circumsporozoite protein (CSP) has been hindered by ...
Ana Rafaela Teixeira, Ana Rafaela Teixeira, Ana Rafaela Teixeira, Begoña Pérez-Cabezas, Begoña Pérez-Cabezas, David M. Costa, David M. Costa, Mónica Sá, Mónica Sá, Mónica Sá, Sylvain Golba, Hélèna Sefiane-Djemaoune, Joana Ribeiro, Joana Ribeiro, Izumi Kaneko, Shiroh Iwanaga, Masao Yuda, Moriya Tsuji, Silvia Beatriz Boscardin, Silvia Beatriz Boscardin, Rogerio Amino, Anabela Cordeiro-da-Silva, Anabela Cordeiro-da-Silva, Anabela Cordeiro-da-Silva, Joana Tavares, Joana Tavares, Joana Tavares   +26 more
doaj   +1 more source