Results 81 to 90 of about 1,607,402 (303)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Behavioral and Reproductive Response of White Pine Weevil (Pissodes strobi) to Resistant and Susceptible Sitka Spruce (Picea sitchensis)

open access: yesInsects, 2010
White pine weevil (Pissodes strobi, Peck.) is a native forest insect pest in the Pacific Northwest of North America that attacks species of spruce (Picea spp.) and pine (Pinus spp.).
Jeanne A. Robert, Jörg Bohlmann
doaj   +1 more source

Dusty Exoplanetary Debris Disks in the Single-Temperature Blackbody Plane [PDF]

open access: yes, 2018
The 21st European Workshop on White Dwarfs was held in Austin, TX from July 23rd to 27th of 2018We present a bulk sample analysis of the metal polluted white dwarfs which also host infrared bright dusty debris disks, known to be direct signatures of ...
Clemens, J. Christopher   +2 more
core   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Host Plant Specialization Driven by Sexual Selection [PDF]

open access: yesThe American Naturalist, 2007
We propose a new mechanism based on sexual selection to explain the evolution of diet breadth in insects. More specifically, we show that mate choice in females for certain diet-derived male pheromones can be exploited by maternal effect genes that preferentially place offspring on a specific host plant, resulting in specialization.
Quental, Tiago   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Suitability and Profitability of a Cereal Aphid for the Parasitoid Aphidius platensis in the Context of Conservation Biological Control of Myzus persicae in Orchards

open access: yesInsects, 2020
The use of cover crops can promote the abundance and early arrival of populations of natural enemies. Cereal cover crops between orchards rows could encourage the early arrival of the parasitoid Aphidius platensis, as they offer alternative winter hosts (
Jeniffer K. Alvarez-Baca   +4 more
doaj   +1 more source

The effect of environmental heterogeneity on RPW8-mediated resistance to powdery mildews in Arabidopsis thaliana [PDF]

open access: yes, 2012
Background and Aims: The biotic and abiotic environment of interacting hosts and parasites may vary considerably over small spatial and temporal scales. It is essential to understand how different environments affect host disease resistance because this ...
Agrios   +70 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Graphosoma lineatum L. Heteroptera, Pentatomidae ’un farklı besinlerdeki biyolojik parametrelerinin belirlenmesi

open access: yesJournal of Agricultural Sciences, 2009
Süne Eurygaster spp. yumurta parazitoitleri için uygun konukçu olan Grapohosoma lineatum L. ’un fekonditesi, erginlerin yaşam süreleri, preovipozisyon, ovipozisyon, postovipozisyon süreleri ile nimflerinin toplam gelişme süresi, dönemlerine göre ...
Gö -   +7 more
doaj  

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