Results 111 to 120 of about 433,979 (304)
From Mario to Manhunt: The Effects ofViolent Video Game Content and Competition on Hostility and Aggressive Cognitions [PDF]
, 2008 Research has shown that playing violent video games can lead to increases in aggressive thoughts, feelings, and behaviors. This study further examined this effect using a specially designed video game that allowed for precise manipulation ofviolent game ...
Lee \u2708, Courtney
core +1 more source
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Mobile solidarities: The City of Sanctuary movement and the Strangers into Citizens campaign
, 2009 Political and social concerns regarding the negative impact of migrants and asylum seekers on local communities have become widespread within the UK over recent years.
Squire, Vicki
core
Administering Suspect Classes [PDF]
, 2017 It has been over forty years since the Supreme Court declared a class suspect under the Equal Protection Clause. In that time, the Court has denied suspect-class status—and the special judicial protections associated with it—to the elderly, the disabled,
Ross, Bertrall L, II
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
The Role of Aggravated Offences in Combating Hate Crime – 15 years after the CDA 1998 – Time for a change? [PDF]
, 2014 The racially aggravated offences created by the 1998 Act (later extended to religious aggravation) were based on a rather arbitrary selection of underlying crimes and have proved difficult to interpret and apply for a number of reasons.
Taylor, Richard D
core
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Race riots on the beach: A case for criminalising hate speech? [PDF]
, 2008 noThis paper analyses the verbal and textual hostility employed by rioters, politicians and the media in Sydney (Australia) in December 2005 in the battle over Sutherland Shire¿s Cronulla Beach.
Asquith, Nicole
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source