Results 231 to 240 of about 433,979 (304)

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Co-occurrence of symptoms of substance and behavioral addictions over time: A secondary analysis of longitudinal data from the Cohort Study on Substance Use Risk Factors. [PDF]

J Behav Addict
Zagaria A, Rogier G, Gmel G, Amendola S.
europepmc   +1 more source

Callous-Unemotional Traits and Gun Violence: The Unique Role of Maternal Hostility. [PDF]

Children (Basel)
Thomson ND, Kjærvik SL, Zacharaki G, Gresham AM, Dick DM, Fanti KA.   +5 more
europepmc   +1 more source

Longitudinal network analysis of mental health trends in Chinese university freshmen: a decadal study (2014-2023). [PDF]

Front Psychol
Teng X, Wang X, Liu Y, Wu D, Dong Z, Lyu S.   +5 more
europepmc   +1 more source

Digital Hostility Toward LGBTQIA+ Research Recruitment on Social Media Using Topic Modeling and Sentiment Analysis of Facebook Comments: Quantitative Content Analysis Study.

J Med Internet Res
Rodriguez VJ, Peterson B, Benhayoun A, Liu Q.   +3 more
europepmc   +1 more source

Early Parenting Effects on Childhood Delay of Gratification and Adolescent Allostatic Load. [PDF]

Children (Basel)
Leonard H, Khurana A, Kosty D.
europepmc   +1 more source