Results 81 to 90 of about 10,320 (215)

Liver Gene Therapy in Fabry Disease Mice With Low Doses of rAAV2/8 Expressing a Codon‐Optimized hGLA cDNA Results in Long‐Term Disease Correction

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
AAV‐mediated gene therapy targets the liver to produce and secrete into circulation functional α‐Gal A, which is taken up by tissues to reduce glycosphingolipid accumulation and prevent disease progression in juvenile Fabry mice, even at low AAV doses. ABSTRACT Fabry disease (FD) is an X‐linked lysosomal storage disorder caused by mutations in the GLA ...
Himanshi Saxena, Rossana Domenis, Giulia Romano, Jessica Biasizzo, Martina Ferro, Dania Ferino, Antonio Vicidomini, Alessandra Iaconcig, Giulia Bortolussi, Lorena Zentilin, Andrea Dardis, Andrés F. Muro   +11 more
wiley   +1 more source

Multi‐Omic Assessment of Microbial Communities and Their Polyketide Biosynthetic Potential Across Abyssal Sediments

Environmental Microbiology, Volume 28, Issue 5, May 2026.
Abyssal sediments were assessed for taxonomic diversity and polyketide biosynthetic potential and compared to metagenomic and metabolomic assessments of the same sediments. Biodiversity differences were documented across biogeochemical regimes with the results providing baseline awareness of what might be lost should deep‐sea microbiomes be disrupted ...
Hans W. Singh, Johanna Gutleben, Alexander Bogdanov, Alexander B. Chase, Alyssa Demko, Sheila Podell, Brian Haley, Paul R. Jensen   +7 more
wiley   +1 more source

Development of Polymer Hydrophobic Surfaces Through Combined Laser Ablation and Hot Embossing Processes

Journal of Manufacturing and Materials Processing
The development of hydrophobicity on polymer surfaces in mass production is one of the most critical challenges in the plastic industry. This paper deals with a novel combined hot embossing process in which femtosecond laser ablation is utilized to ...
Esmaeil Ghadiri Zahrani, Amirmohmmad Fakharzadeh Jahromi, Bahman Azarhoushang   +2 more
doaj   +1 more source

Fabrication of 3D nano-hemispherical cavity array plasmonic substrate for SERS applications

International Journal of Optomechatronics, 2018
Surface-enhanced Raman scattering (SERS) have numerous applications in areas such as analytical chemistry, biochemistry, and environmental science. However to manufacture SERS active substrates with good reproducibility and low cost is not easy, which ...
Chu-Yu Huang, Ming-Shiuan Tsai
doaj   +1 more source

Increased efficiency of direct nanoimprinting on planar and curved bulk titanium through surface modification [PDF]

, 2013
In this work the direct transfer of nanopatterns into titanium is demonstrated. The nanofeatures are imprinted at room temperature using diamond stamps in a single step.
Ali Z. Khokhar, Alistair S. Brydone, Andrew I.M. Greer, Asokan, Blau, Britton, Cho, Dalby, David A.J. Moran, den Braber, Greer, Greer, Hunt, Ian MacLaren, Kern, Kim, Krishna Seunarine, Landolt, Li, Lister, Liu, Murali, Narutani, Nikolaj Gadegaard, Nix, Pang, Pei, Pethica, Pornsin-siriak, Savvides, Shuman, Stokes, Taniguchi, Vlassak, Zhu, Zhu   +35 more
core   +1 more source

Combined Foaming and Surface Structuring of Polymers With Supercritical Carbon Dioxide (scCO2) Applying an Incomplete Saturation Strategy

Journal of Applied Polymer Science, Volume 143, Issue 15, April 15, 2026.
Combined foaming and structuring of polymer samples by processing with supercritical CO2 leads to nano‐ and microstructured surfaces on top of perfectly white polymer sheets. ABSTRACT Supercritical carbon dioxide (scCO2) is a widely applied solvent utilized in many physical–chemical processes, including the foaming or structuring of polymers.
Luisa Maren Borgmann, Ester Priante, Siegbert Johnsen, Marc Schneider, Markus Guttmann, Benedikt Bläsi, Gabriele Wiegand, Hendrik Hölscher   +7 more
wiley   +1 more source

On‐Demand Cargo Release via Low‐Voltage Actuated Flexible Microchamber Arrays

Advanced Materials Technologies, Volume 11, Issue 8, 17 April 2026.
On‐demand triggering of cargoes’ release from free standing array of biocompatible microchambers may be actuated by electrical stimuli at voltages as low as 1 V, even making them suitable for implantation in living beings for drug delivery purposes.
Stefania Boi, Valentina Ricci, Maddalena Botti, Simone L. Marasso, Valentina Sinisi, Davide Vurro, Rishit Mohan Ahuja, Alberto Ballesio, Matteo Cocuzza, Saksham Sharma, Giuseppe Tarabella, Salvatore Iannotta, Pasquale D'Angelo   +12 more
wiley   +1 more source

Hot Embossing of Zr-Based Bulk Metallic Glass Micropart Using Stacked Silicon Dies

Advances in Materials Science and Engineering, 2015
We demonstrated hot embossing of Zr65Cu17.5Ni10Al7.5 bulk metallic glass micropart using stacked silicon dies. Finite element simulation was carried out, suggesting that it could reduce the stress below 400 MPa in the silicon dies and enhance the ...
Zhijing Zhu, Chuanyun Yi, Tielin Shi, Yichun Zhang, Yang Gao, Guanglan Liao   +5 more
doaj   +1 more source

Holding fixture for a hot stamping press [PDF]

, 1983
A hand held guide for manually positioning a work piece between the anvil rib and tool of a hot die stamping press is described. A groove completed by interchangeable cover plates attached at one end of the guide conforms to a cross sectional dimension ...
Harris, R. P.
core   +1 more source

Hot punching of high-aspect-ratio 3D polymeric microstructures for drug delivery [PDF]

, 2015
Hot punching: a highly versatile method of fabricating high-aspect-ratio 3D microstructures for drug delivery with good replication fidelity and yield.
Boisen, Anja, Keller, Stephan Sylvest, Petersen, Ritika Singh   +2 more
core   +1 more source