Results 221 to 230 of about 1,477,069 (292)

Analgesic and anti-inflammatory activities of Vitex trifolia extract and development of a topical herbal cream. [PDF]

J Ayurveda Integr Med
Paduka W, Kunworarath N, Mahaprom K, Naphatthalung J, Chokpaisarn J.   +4 more
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Contrasting slab decarbonation patterns control deep carbon cycling efficiency in hot vs. cold subduction zones. [PDF]

Sci Adv
Zhang H, Wang Y, Li ZH, Gerya TV, Li HY, Wang SJ, Zhou X, Deng Y, Wang Y, Morgan JP.   +9 more
europepmc   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Exploring the role of alpha-tocopherol in pain and inflammation: interplay with TRPV1, PKA, and PKC pathways. [PDF]

Korean J Pain
Jaffal S, Oran S.
europepmc   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Evaluation of Intravenous Lipid Emulsion as an Adjunctive Antidote in Experimental Fentanyl Toxicity: Comparison with Naloxone in a Rat Model. [PDF]

Int J Mol Sci
Kehayova G, Yarabanova I, Stoeva-Grigorova S, Hvarchanova N, Radeva-Ilieva M, Stoychev E, Dragomanova S, Dimitrova S, Zlateva S, Marinov P.   +9 more
europepmc   +1 more source

Surface Neuronal‐Like Structuring of High‐Strength CFRP for Enhanced Electromagnetic Interference Shielding

Advanced Science, EarlyView.
This study elucidates the microstructural evolution at the material interface of Ni‐plated plain‐weave carbon fiber fabric following vacuum heat treatment at 500°C–900°C under different current densities, as well as the mechanism underlying the synergistic enhancement of electromagnetic shielding and ductility.
Wei Cheng, Ben Jia, Shuhan Xiang, Biao Chen, Yongjun Zhang, Zhuo Liu, Xiaopeng Wan, Heyuan Huang   +7 more
wiley   +1 more source

The mechanosensitive channel TMEM63B contributes to noxious heat sensation in the dorsal root ganglia. [PDF]

PLoS Biol
Ye C, Zang YY, Duan GF, Chen J, Wu D, Wang D, Li C, Xu Y, Xia T, Gu X, Shi YS.   +10 more
europepmc   +1 more source

Top-down control of the descending pain modulatory system drives multimodal placebo analgesia. [PDF]

Neuron
Livrizzi G, Chang-Weinberg J, Johnson DA, Lubejko ST, Liao J, Kimmey BA, Dong C, Li Y, Beier KT, Corder G, Tian L, Banghart MR.   +11 more
europepmc   +1 more source