Results 31 to 40 of about 93,608 (260)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Tracing Hot Spot Motion in Sagittarius A* Using the Next-Generation Event Horizon Telescope (ngEHT)

Galaxies, 2023
We propose the tracing of the motion of a shearing hot spot near the Sgr A* source through a dynamical image reconstruction algorithm, StarWarps. Such a hot spot may form as the exhaust of magnetic reconnection in a current sheet near the black hole ...
Razieh Emami, Paul Tiede, Sheperd S. Doeleman, Freek Roelofs , Maciek Wielgus , Lindy Blackburn , Matthew Liska , Koushik Chatterjee , Bart Ripperda, Antonio Fuentes , Avery E. Broderick, Lars Hernquist , Charles Alcock , Ramesh Narayan, Randall Smith , Grant Tremblay, Angelo Ricarte, He Sun, Richard Anantua , Yuri Y. Kovalev , Priyamvada Natarajan, Mark Vogelsberger   +21 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The geno-spatio analysis of Mycobacterium tuberculosis complex in hot and cold spots of Guangxi, China

BMC Infectious Diseases, 2020
Background At present, there are few studies on polymorphism of Mycobacterium tuberculosis (Mtb) gene and how it affects the TB epidemic. This study aimed to document the differences of polymorphisms between tuberculosis hot and cold spot areas of ...
Dingwen Lin, Zhezhe Cui, Virasakdi Chongsuvivatwong, Prasit Palittapongarnpim, Angkana Chaiprasert, Wuthiwat Ruangchai, Jing Ou, Liwen Huang   +7 more
doaj   +1 more source

Applying machine learning techniques to predict detonation initiation from hot spots

Energy and AI, 2022
As hot spots can be a source of detonation initiation by autoignition in a reactive mixture, understanding hot spot initiated detonation is significantly important for energy-related applications of detonation. Although the Zel’dovich reactivity gradient
Je Ir Ryu
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

An Edge-Guided Deep Learning Solar Panel Hotspot Thermal Image Segmentation Algorithm

Applied Sciences, 2023
To overcome the deficiencies in segmenting hot spots from thermal infrared images, such as difficulty extracting the edge features, low accuracy, and a high missed detection rate, an improved Mask R-CNN photovoltaic hot spot thermal image segmentation ...
Fangbin Wang, Zini Wang, Zhong Chen, Darong Zhu, Xue Gong, Wanlin Cong   +5 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A fault diagnosis method of hot spots for photovoltaic clusters based on model parameters

Energy Science & Engineering
Utilizing the direct current‐side electrical data resources of the photovoltaic power generation system on the FusionSolar platform, this study investigates the impact of hot spot faults on the output characteristics of photovoltaic strings and proposes ...
Chi Xiaoni, Dong Wei, Yunxiao He, Minxiang Shen   +3 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source