Results 151 to 160 of about 117,287 (255)

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

Integrative analytical and statistical framework for optimization of multiplex qPCR detection of <i>TGFBI</i> mutations in refractive surgery candidates. [PDF]

J Zhejiang Univ Sci B
Gu Y, Mao L, Li X, Sun K, Jiang Q, Wu W, Shen Y, Chen S, Zheng M, Xu Y.   +9 more
europepmc   +1 more source

Full‐Stack Architectures for Intelligent Brain‐Computer Interfaces

Advanced Science, EarlyView.
System‐level overview of brain–computer interfaces (BCIs), illustrating the integration of neural signal acquisition, wireless transmission, and adaptive decoding. Advanced electrode, tissue interfaces, energy‐efficient communication, and robust algorithms collectively enable stable signal quality, real‐time processing, and closed‐loop operation ...
Hee Kyu Lee, Hyun Bin Kim, Sang Uk Park, Janghoon Joo, Jinhong Min, Geumbee Lee, Joohoon Kang, Hyoyoung Jeong, Jae‐Young Yoo, Sang Min Won   +9 more
wiley   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Geospatial heterogeneity of hotspots for incidence and late-stage diagnosis of breast, colorectal, and lung cancer. [PDF]

Cancer Causes Control
Loehrer AP, Carlos HA, Weiss JE, Wang Q, Leversedge CV, Katter JE, Phillips JD, Ferrari-Light D, Onega T, Shi X.   +9 more
europepmc   +1 more source

Synergistic Stabilization of Potassium Metal Anodes Through Orange‐Peel Elimination and Robust Solid–Electrolyte Interphase Formation

Advanced Science, EarlyView.
Synergistic control of surface uniformity and solid–electrolyte interphase robustness regulates potassium deposition, suppressing dendritic growth and enabling uniform, dense potassium plating. This combined strategy promotes stable interfacial chemistry and homogeneous electric‐field distribution, leading to enhanced reversibility and long‐term ...
Pan He, Yupei Han, Yundong Zhou, Ruhan He, Rui Xu, Yunlong Zhao, Junjun Wang, Wanjun Ren, Matthew Hopper, Qinyou An, Denys Makarov, Ian S. Gilmore, Liqiang Mai, Yang Xu   +13 more
wiley   +1 more source

New genotyping method for Escherichia coli using RSXC repeat polymorphism and gene-neighborhood architecture. [PDF]

BMC Genomics
Jothi R, Park KM, Yim S, Oh KK, Hwang I, Jeong MI, Park DS.   +6 more
europepmc   +1 more source

Large Temperature‐invariant Anomalous Nernst Effect in Non‐collinear Antiferromagnet Mn3Pt

Advanced Science, EarlyView.
Based on the noncollinear antiferromagnetic Mn3Pt thin films, the composition‐tunable Mn‐3d orbital states directly govern the Berry curvature. As a result, a giant and temperature‐invariant anomalous Nernst coefficient of 0.71 µV/K is achieved under Mn‐rich conditions.
Pengwei Gong, Xiaolin Zhang, Wei Zhu, Mingzhi Wang, Chang Pan, Aoqi Xu, Yandong Guo, Yuheng Li, Jiaxin Chen, Yanchang Zhou, Zhong Shi, Dingfu Shao, Liang Liu, Shiming Zhou, Yicheng Guan, Ruiqing Cheng, Xuepeng Qiu   +16 more
wiley   +1 more source

Tumour necrosis as a prognostic indicator in hepatocellular carcinoma. [PDF]

BMC Cancer
Sarelin N, Kairaluoma V, Saarnio J, Kauppila JH, Böhm J, Huhta H, Helminen O, Väyrynen JP.   +7 more
europepmc   +1 more source

Intramolecular Interactions between Folded and Disordered Regions Shape Ubiquilin Structure and Function

Advanced Science, EarlyView.
Ubiquilin (UBQLN), like many other human proteins, contains both well‐folded and disordered regions. Here, we show that intramolecular interactions between disordered regions and folded domains modulate between open and closed topologies of UBQLN proteins, altering their structure and function.
Jessica K. Niblo, Nirbhik Acharya, Maxwell B. Watkins, Carlos A. Castañeda, Shahar Sukenik   +4 more
wiley   +1 more source