Results 171 to 180 of about 331,632 (308)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Fentanyl's Deadly Footprint: A New Framework for Predicting Overdose Hotspots. [PDF]

Cureus
Okunola D, Alabi A, Akinpeloye O, Izinyon O, Amusa T.   +4 more
europepmc   +1 more source

Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

, 2019
Anna‐Liisa Laine, Benoît Barrès, Elina Numminen, Jukka Sirén   +3 more
openalex   +2 more sources

P2451Epidemiology of heart failure in Australia: evidence of developing world hotspots in a high income country [PDF]

, 2017
S. Booley, Lingwei Chen, Ashley K. Keates, Alice David, C. Mainland, J. Harris, Simon Stewart   +6 more
openalex   +1 more source

Targeting the GPX4–FUNDC1 Interaction with Magnesium Lithospermate B Attenuates Sepsis‐Associated Lung Injury

Advanced Science, EarlyView.
The diagram depicts the endothelial‐protective mechanism of magnesium lithospermate B (MLB) in sepsis‐associated lung injury. MLB binds GPX4 at Gly79, disrupts its interaction with FUNDC1, prevents mitophagy‐mediated GPX4 degradation, restores mitophagic flux, reduces ROS, and limits ferroptosis.
Zhixi Li, Chang Liu, Zhaoxue Ma, Dongyou Zheng, Renkai Wang, Yongjing Yu, Guangmin Chen, Chenglong Li, Yue Bu, Hang Cao, Bing Zhang   +10 more
wiley   +1 more source

Context-level machine learning to improve the identification of lymph node and bone metastases in prostate cancer patients using [¹⁸F]PSMA-1007 PET. [PDF]

EJNMMI Phys
Poelarends RJ, van Dalen JA, Vendel BN, Stevens H, van Dijk JD.   +4 more
europepmc   +1 more source

Microhematuria prevalence in hotspot implementation units.

Lydia Trippler (10136316), Said Mohammed Ali (10136325), Mohammed Nassor Ali (11951653), Ulfat Amour Mohammed (21464210), Khamis Rashid Suleiman (13002039), Naomi Chi Ndum (21464213), Saleh Juma (6577406), Shaali Makame Ame (13002033), Fatma Kabole (3590819), Jan Hattendorf (113923), Stefanie Knopp (108848)   +10 more
openalex   +1 more source

Centenarian Hotspots in Denmark [PDF]

, 2017
Anne Vinkel Hansen, Laust Hvas Mortensen, Rudi G. J. Westendorp   +2 more
openalex   +1 more source

Photothermal Transport for Guiding Nanoparticles Through the Vitreous Humor

Advanced Science, EarlyView.
Nanosecond laser irradiation of the clinically approved dye indocyanine green (ICG) enables light‐guided nanoparticle transport within the vitreous humor. The combined use of ICG and pulsed laser illumination induces localized convection and thermophoresis, directing particles toward illuminated regions.
Léa Guerassimoff, Yera Ussembayev, Louise De Clerck, Deep Punj, Martijn van den Broek, Filip Beunis, Katrien Remaut, Kevin Braeckmans, Stefaan C. De Smedt, Félix Sauvage   +9 more
wiley   +1 more source

Impact Analysis of the Market Penetration Rate of Connected Vehicles and the Failure Rate of Roadside Equipment on Data Accuracy. [PDF]

Sensors (Basel)
Zhan F.
europepmc   +1 more source