Results 171 to 180 of about 335,663 (313)

Global analyses of genomic and epigenomic influences on gene expression reveal <i>Serpina3n</i> as a major regulator of cardiac gene expression in response to catecholamine challenge during heart failure. [PDF]

Epigenetics
Lahue C, Ravindran S, Dalal A, Avetisyan R, Rau CD.   +4 more
europepmc   +1 more source

Highly resonant graphene plasmon hotspots in complex nanoresonator geometries

, 2019
William S. Hart, Vishal Panchal, Christos Melios, Włodek Strupiński, Olga Kazakova, Chris C. Phillips   +5 more
openalex   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation. [PDF]

PLoS Comput Biol
Schultheiss DL, Turi Z, Boedecker J, Vlachos A.   +3 more
europepmc   +1 more source

Sea ice and a wastewater outlet identified as hotspots for anthropogenic microlitter in Svalbard waters

, 2020
Lisa W. von Friesen, Maria Granberg, Olga Pavlova, Kerstin Magnusson, Martin Hassellöv, Geir Wing Gabrielsen   +5 more
openalex   +1 more source

Climate Action Impacts on Steelmaking Emissions of Persistent Organic Pollutants Highlight a Gap Between the Paris Agreement and the Stockholm Convention

Advanced Science, EarlyView.
Emissions of unintentionally produced persistent organic pollutants (UPOPs) and global warming are two major environmental challenges. But their governance has largely evolved in parallel, leaving the toxicity implications of climate‐driven industrial transitions poorly understood.
Yuxiang Sun, Qiuting Yang, Jianghui Yun, Yujue Yang, Junhao Tang, Qian Liu, Minghui Zheng, Guorui Liu   +7 more
wiley   +1 more source

Mapping of sex work hotspots to guide targeted HIV prevention: Evidence from eight Ukrainian cities. [PDF]

PLoS One
Kovtun O, Cheshun O, Pashchuk O, Dumchev K.   +3 more
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Hotspot Interactions between Two Fab Molecules in Molecular Dynamics Simulations Improve Predictive Models of Aggregation Kinetics. [PDF]

Mol Pharm
Wang Y, Williams HD, Dikicioglu D, Dalby PA.   +3 more
europepmc   +1 more source

SARS‑CoV‑2 mutation hotspots incidence in different geographic regions [PDF]

, 2020
Jivan Q. Ahmad, Gahin Abdulraheem Tayib, Teroj A. Mohamed   +2 more
openalex   +1 more source