Results 231 to 240 of about 331,632 (308)

Synergistic Effects of Solid Electrolyte Mild Sintering and Lithium Surface Passivation for Enhanced Lithium Metal Cycling in All‐Solid‐State Batteries

Advanced Science, EarlyView.
This study proposes a synergistic strategy combining mild sintering of solid electrolyte pellets with lithium metal surface passivation, effectively suppressing dendrite growth, and enhancing interfacial stability. This approach doubles the critical current density of symmetric cells (1.1 to 2.2 mA cm−2) and extends full cells cycle life at 1 mA cm−2 ...
Jinsong Zhang, Robin N. Wullich, Thomas J. Schmidt, Mario El Kazzi   +3 more
wiley   +1 more source

Integrative clinico-molecular analysis reveals actionable subtypes and biomarkers in lung adenocarcinoma. [PDF]

Cell Discov
Shang J, Jiang H, Yan Y, Zhao Y, Yang J, Han H, Yuan H, Shi L, Zheng Y, Chen H.   +9 more
europepmc   +1 more source

Ubiquitination‐Driven Reprogramming of Proteostasis in Metastasis

Advanced Science, EarlyView.
The DCAF12–TRiC/CCT axis is a key regulator of metastasis in cancer. By reprogramming proteostasis to ensure efficient protein folding, it drives progression through a dual mechanism: enhancing cancer cell motility and invasiveness while concurrently activating pro‐growth and survival pathways.
Dongping Wei, Jiayan Chen, Yaping Xu
wiley   +1 more source

Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. [PDF]

Nat Genet
Boscenco S, Tait-Mulder J, Kim M, Tang C, Park T, McNulty F, Lilla S, Zanivan S, Huerta-Uribe A, Nalbant B, Zucker M, Sumpton D, Monteuuis G, Jackson CB, Wei W, Chinnery PF, Chaligne R, Lareau CA, Reznik E, Gammage PA.   +19 more
europepmc   +1 more source

Metformin‐Based Covalent Organic Frameworks With Excellent Biosafety and High Efficiency against Pathogenic Microorganisms

Advanced Science, EarlyView.
This work presents the first metformin‐based COFs featuring built‐in biosafety and a unique triple‐synergy mechanism. This scalable platform achieves broad‐spectrum eradication of bacteria and viruses, enabling reusable protective membranes with exceptional biocompatibility for advanced biomedical applications and personal protection.
Jia‐Yi Liu, Hong Jiang, Lei Ma, Jin‐Yi Yu, Ming‐Yi Yang, Hao‐Ru Wang, Jun‐Yuang Tang, Shengfeng Huang, Wei Yi, Meng Lu, Ya‐Qian Lan, Xu‐Jia Hong   +11 more
wiley   +1 more source

Smartphone-based retrospective analysis for malaria hotspot detection. [PDF]

Einstein (Sao Paulo)
da Silva BM, Giddaluru J, Cardozo LE, Martins FM, Antolini APR, Bargieri DY, de Lacerda MVG, Monteiro WM, Sampaio VS, Nakaya HI.   +9 more
europepmc   +1 more source

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Correlation of MLASA2 Clinical Phenotype and Survival with Mt-TyrRS Protein Damage: Linking Systematic Review, Meta-Analysis and 3D Hotspot Mapping. [PDF]

Curr Issues Mol Biol
Villafan-Bernal JR, Martínez-Hernández A, García-Ortiz H, Contreras-Cubas C, Guerrero-Contreras I, Frías-Cabrera JL, Centeno-Cruz F, Morales Rivera MI, Hernández JR, Carnevale A, Barajas-Olmos F, Orozco L.   +11 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source