Results 31 to 40 of about 117,287 (255)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Steady-State Simulation of a Fixed-Bed Reactor for the Total Oxidation of Volatile Organic Components: Application of the Barkelew Criterion

ChemEngineering
A steady-state tubular reactor for total oxidation reaction under typical industrial conditions in the removal of volatile organic components (VOC) is described using a one-dimensional heterogeneous reactor model with intraparticle diffusion, using a ...
Philippe M. Heynderickx, Joris W. Thybaut   +1 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Three new species of Niphargidae family added to the list of subterranean amphipods (Crustacea: Amphipoda) in Slovenia

Natura Sloveniae
Since the last comprehensive checklist of amphipods in 2021, three new species of subterranean amphipods have been confirmed for Slovenia: Niphargus danielopoli, N. lurensis and N. julius.
Cene Fišer, Teo Delić, Maja Zagmajster
doaj   +1 more source

Post-translational Modification Crosstalk and Hotspots in Sirtuin Interactors Implicated in Cardiovascular Diseases

Frontiers in Genetics, 2020
Sirtuins are protein deacetylases that play a protective role in cardiovascular diseases (CVDs), as well as many other diseases. Absence of sirtuins can lead to hyperacetylation of both nuclear and mitochondrial proteins leading to metabolic ...
Suruchi Aggarwal, Suruchi Aggarwal, Suruchi Aggarwal, Sanjay K. Banerjee, Narayan Chandra Talukdar, Narayan Chandra Talukdar, Amit Kumar Yadav   +6 more
doaj   +1 more source

Pola Distribusi Spasial-Temporal Hotspot dan Variasi Standardized Precipitation Index pada Lahan Gambut Tropis di Kepulauan Meranti, Riau

Jurnal Ilmu Lingkungan, 2022
Kebakaran hutan dan lahan yang terjadi setiap tahun di Indonesia sebagian besar berlokasi di lahan gambut. Bencana tersebut berdampak besar terhadap berbagai aspek kehidupan, salah satunya adalah terdegradasinya lahan gambut tropis.
Maulana Dwi Putra Riyadi, Yudi Setiawan, Muh Taufik   +2 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Recognizing hotspots in Brief Eclectic Psychotherapy for PTSD by text and audio mining

European Journal of Psychotraumatology, 2020
Background: Identifying and addressing hotspots is a key element of imaginal exposure in Brief Eclectic Psychotherapy for PTSD (BEPP). Research shows that treatment effectiveness is associated with focusing on these hotspots and that hotspot frequency ...
Sytske Wiegersma, Mirjam J. Nijdam, Arjan J. van Hessen, Khiet P. Truong, Bernard P. Veldkamp, Miranda Olff   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source