Results 41 to 50 of about 267,219 (299)
Structural identification of a hotspot on CFTR for potentiation
Science, 2019 Keeping the gate open Cystic fibrosis is a progressive disease that affects lung function and is often fatal. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR).
Fangyu Liu +6 more
semanticscholar +1 more source
Frontiers in Microbiology, 2022 BackgroundVisceral leishmaniasis (VL) is a serious vector-borne disease in central and western China. In recent years, the number of VL cases increased gradually, particularly the mountain-type zoonotic visceral leishmaniasis (MT-ZVL).
Yuanyuan Li +9 more
doaj +1 more source
A Clustering Based Hotspot Identification Approach For Crime Prediction
Procedia Computer Science, 2020 With the emergence in the field of crime prediction, researchers found that crime shows geographical patterns. These patterns can be useful to predict crime before it happens and allows police to take proactive measures.
Gaurav Hajela, M. Chawla, A. Rasool
semanticscholar +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Experimenting with a Battery-Based Mitigation Technique for Coping with Predictable Partial Shading
Energies, 2022 In this paper, the authors propose to use batteries to improve the performance of grid-connected photovoltaic plants when their photovoltaic fields are subject to partial shading phenomena.
Rosario Carbone, Cosimo Borrello
doaj +1 more source
Somatic SF3B1 hotspot mutation in prolactinomas
Nature Communications, 2020 The genetic basis and corresponding clinical relevance of prolactinomas remain poorly understood. Here, we perform whole genome sequencing (WGS) on 21 patients with prolactinomas to detect somatic mutations and then validate the mutations with digital ...
Chuzhong Li +24 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
ChemEngineeringA steady-state tubular reactor for total oxidation reaction under typical industrial conditions in the removal of volatile organic components (VOC) is described using a one-dimensional heterogeneous reactor model with intraparticle diffusion, using a ...
Philippe M. Heynderickx +1 more
doaj +1 more source
Frontiers in Genetics, 2020 Sirtuins are protein deacetylases that play a protective role in cardiovascular diseases (CVDs), as well as many other diseases. Absence of sirtuins can lead to hyperacetylation of both nuclear and mitochondrial proteins leading to metabolic ...
Suruchi Aggarwal +6 more
doaj +1 more source