Results 61 to 70 of about 335,663 (313)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Updating the Earth remote sensing software for the detection of thermal anomalies

Informatika, 2021
O b j e c t i v e s. The task of improving the software package for detecting thermal anomalies based on meteorologicalsatellite data developed by the unitary enterprise "Geoinformation Systems" was solved.M e t h o d s.
S. A. Zolotoy, I. B. Strashko, Dz. S. Kotau, I. M. Nestsiarovich, V. V. Rouba, Dz. V. Valakhovich   +5 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

A Framework Analyzing Climate Change, Air Quality and Greenery to Unveil Environmental Stress Risk Hotspots

Remote Sensing
Rapid urbanization has resulted in increased environmental challenges, compounding worries about deteriorating air quality and rising temperatures. As cities become hubs of human activity, understanding the complex interplay of numerous environmental ...
Priyanka Rao, Patrizia Tassinari, Daniele Torreggiani   +2 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Violence indicators and healt of refugees/asylum sekeers: the first five days [PDF]

, 2017
The contribution describes the results of a qualitative research with women refugees/asylum seekers in some first reception centers (Hotspot and CAS) of western ...
Bartholini I
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Behavioral hotspots of bottlenose dolphins in industrialized ship channels

Frontiers in Marine Science
Anthropogenic activity in coastal areas can damage marine habitats and alter marine mammal behavior and habitat use. Understanding behavioral associations with diverse habitat features in industrialized coastal areas is crucial for marine mammal ...
Eliza M. M. Mills, Sarah Piwetz, Dara N. Orbach   +2 more
doaj   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Unusual linewidth dependence of coherent THz emission measured from intrinsic Josephson junction stacks in the hot-spot regime

, 2012
We report on measurements of the linewidth {\Delta}f of THz radiation emitted from intrinsic Josephson junction stacks, using a Nb/AlN/NbN integrated receiver for detection. Previous resolution limited measurements indicated that {\Delta}f may be below 1
A. I. Larkin, Akira Ishii, Boris Gross, Dieter Koelle, Huabing Wang, J. R. Hendrickson, Jie Yuan, Jun Li, Kazuto Hirata, Mengyue Li, Nickolay Kinev, Peiheng Wu, Reinhold Kleiner, Stefan Guénon, Takeshi Hatano, Valery P. Koshelets   +15 more
core   +1 more source