Results 81 to 90 of about 23,287,430 (320)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Spatio-Temporal Investigations of Dengue Fever in Pakistan Through an HL7 Based Public Health Framework for Hotspot Analysis

IEEE Access, 2020
The importance of a standard based interoperability framework is now widely recognized. In order to understand the challenges, feasibility and impact of outcomes of such architectures for public health improvement, it is important to implement and ...
Fatima Khalique, Rubina Shaheen, Shoab Ahmed Khan   +2 more
doaj   +1 more source

Perancangan Sistem Pakar Untuk Mendeteksi Kerusakan Teknis Jaringan WLAN Dengan Metode Forward Chaining (studi kasus : MH5 NETWORK) [PDF]

, 2016
MH5 network a hotspot network provider organization in a area Cipeundeuy. Internet providers supported by the wireless device and network settings Wireless Local Area Network (WLAN) for the needs of internet connection by network management personnel ...
Doddy Ferdiansyah, DS, INDRA GUNAWAN, 133040018, Iwan Kurniawan, DS   +2 more
core  

ShenZhen transportation system (SZTS): a novel big data benchmark suite [PDF]

, 2016
Data analytics is at the core of the supply chain for both products and services in modern economies and societies. Big data workloads, however, are placing unprecedented demands on computing technologies, calling for a deep understanding and ...
Bei, Zhengdong, Eeckhout, Lieven, Xiong, Wen, Xu, Chengzhong, Yu, Zhibin, Zhang, Fan   +5 more
core   +2 more sources

A comparative analysis of hotspot identification methods

Accident Analysis & Prevention, 2010
The identification of crash hotspots is the first step of the highway safety management process. Errors in hotspot identification may result in the inefficient use of resources for safety improvements and may reduce the global effectiveness of the safety management process. Despite the importance of using effective hotspot identification (HSID) methods,
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

On the interaction of FR-II radio sources with the intracluster medium

, 2002
The effect of the expansion of powerful FR-II radio sources into a cluster environment is discussed. The analysis considers both the thermal and temporal evolution of the ICM which has passed through the bow shock of the radio source and the effect of ...
Alexander, McNamara, P. Alexander
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Spatiotemporal Dynamics and Projections of Carbon Storage Using Integrated PLUS-InVEST Modeling: A Case Study of the Guanzhong Plain Urban Agglomeration, China

Land
Rapid urbanization has driven land-use transitions, leading to the continuous replacement of land-use types with high carbon storage capacity by those with lower capacity.
Zhongzhen Zhu, Yuxi Yang, Yixin Zhang, Ling Qiu, Tian Gao   +4 more
doaj   +1 more source

Revealing the Spatiotemporal Patterns of Anthropogenic Light at Night within Ecological Conservation Redline Using Series Satellite Nighttime Imageries (2000–2020)

Remote Sensing, 2022
With the rapid urbanization process, the construction of lighting facilities is increasing, whereas artificial light at nighttime (ALAN) negatively affects organisms in protected areas and threatens ecosystems.
Fangming Jiang, Yang Ye, Zhen He, Jianwu Cai, Aihua Shen, Rui Peng, Binjie Chen, Chen Tong, Jinsong Deng   +8 more
doaj   +1 more source