Results 161 to 170 of about 85,194 (289)

Fentanyl's Deadly Footprint: A New Framework for Predicting Overdose Hotspots. [PDF]

Cureus
Okunola D, Alabi A, Akinpeloye O, Izinyon O, Amusa T.   +4 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Geospatial modelling for zoonotic disease hotspot identification within a One Health framework: a systematic review. [PDF]

One Health Outlook
Nyengere J, Mbewe W, Malalu L, Tholo H, Njala AL, Sembo T, Kumpolota SW, Mvula RL, Chisenga C, Kanyika-Mbewe C, Maluwa A, Eregno FE.   +11 more
europepmc   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Dendritic compartment-specific spine formation in layer 5 neurons underlies cortical circuit maturation during adolescence. [PDF]

Sci Adv
Egashira R, Ke MT, Nakagawa-Tamagawa N, Fujimoto S, Inagaki S, Takagi T, Miyakawa T, Tagawa Y, Imai T.   +8 more
europepmc   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Lesion topography shapes motor thresholds in brain tumor patients. [PDF]

Neuroimage Clin
Stark A, Goloshchapova K, Spolaore A, Gorbachuk M, Gkampenis A, Wang S, Machetanz K, Tatagiba M, Naros G.   +8 more
europepmc   +1 more source

Updated maps of ghost gears hotspots

Deliverable is one of the results of task 53 related to the mapping of the ghost gear ...
openaire   +1 more source

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Horizontal and vertical exoplanet thermal structure from a JWST spectroscopic eclipse map. [PDF]

Nat Astron
Challener RC, Weiner Mansfield M, Cubillos PE, Piette AAA, Coulombe LP, Beltz H, Blecic J, Rauscher E, Bean JL, Benneke B, Kempton EM, Harrington J, Komacek TD, Parmentier V, Casewell SL, Iro N, Mancini L, Nixon MC, Radica M, Steinrueck ME, Welbanks L, Batalha NM, Caceres C, Crossfield IJM, Crouzet N, Désert JM, Molaverdikhani K, Nikolov NK, Palle E, Rackham BV, Schlawin E, Sing DK, Stevenson KB, Tan X, Turner JD, Zhang X.   +35 more
europepmc   +1 more source