Results 71 to 80 of about 85,194 (289)

Mapping Key Populations to Develop Improved HIV and AIDS Interventions: Multiphase Cross-Sectional Observational Mapping Study Using a District and City Approach

JMIR Public Health and Surveillance
BackgroundIndonesia’s vast archipelago and substantial population size present unique challenges in addressing its multifaceted HIV epidemic, with 90% of its 514 districts and cities reporting cases.
Pande Putu Januraga, Endang Lukitosari, Lanny Luhukay, Rizky Hasby, Aang Sutrisna   +4 more
doaj   +1 more source

A Two-Dimensional Infrared Map of the Extrasolar Planet HD 189733b

, 2012
We derive the first secondary eclipse map of an exoplanet, HD 189733b, based on Spitzer IRAC 8 micron data. We develop two complementary techniques for deriving the two dimensional planet intensity: regularized slice mapping and spherical harmonic ...
Agol, Burrows, Charbonneau, Cooper, Cowan, Crossfield, Deming, Dobbs-Dixon, Fabrycky, Górski, Horne, Knutson, Knutson, Langton, Lanza, Rauscher, Rauscher, Showman, Showman, Showman, Williams, Young, Young   +22 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Under-Canopy Drone 3D Surveys for Wild Fruit Hotspot Mapping

Drones
Advances in mobile robotics and AI have significantly expanded their application across various domains and challenging conditions. In the past, this has been limited to safe, controlled, and highly structured settings, where simplifying assumptions and ...
Paweł Trybała, Luca Morelli, Fabio Remondino, Levi Farrand, Micael S. Couceiro   +4 more
doaj   +1 more source

Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer

Genome Medicine, 2020
Background APOBEC-driven mutagenesis and functional positive selection of mutated genes may synergistically drive the higher frequency of some hotspot driver mutations compared to other mutations within the same gene, as we reported for FGFR3 S249C. Only
Ming-Jun Shi, Xiang-Yu Meng, Jacqueline Fontugne, Chun-Long Chen, François Radvanyi, Isabelle Bernard-Pierrot   +5 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Automated Analysis of Wildlife-Vehicle Conflict Hotspots Using Carcass and Collision Data [PDF]

, 2020
Wildlife-vehicle conflict (WVC) occurs when traffic coincides with a place where animals decide to cross the surface of a roadway. State departments of transportation have a consistent need to understand rates and locations of WVC but inconsistent access
Shilling, Fraser
core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

The effect of fear of crime on public space use: The case of Rüsumat [PDF]

Spatium
The growing populations of today’s cities, as well as the increase in alienation amongst their inhabitants, raises the perception of crime. People’s desire for communal areas such as public spaces is reduced when they feel unsafe in urban places.
Alkan İsra Nur, Kutay Karaçor Elif
doaj   +1 more source