Results 41 to 50 of about 1,353,539 (295)
Cloud Migration: A Case Study of Migrating an Enterprise IT System to IaaS
, 2010 This case study illustrates the potential benefits and risks associated with the migration of an IT system in the oil & gas industry from an in-house data center to Amazon EC2 from a broad variety of stakeholder perspectives across the enterprise, thus ...
Greenwood, David +2 more
core +3 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Um estranho à minha porta: preparando estudantes de medicina para visitas domiciliares
Revista Brasileira de Educação MédicaEste trabalho descreve a experiência de preparação de alunos do primeiro ano da Faculdade de Medicina de Botucatu-Unesp para as visitares domiciliares da disciplina Interação Universidade-Serviço-Comunidade.
Ana Teresa de Abreu Ramos-Cerqueira +3 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A critical focus on digital literacies [PDF]
, 2015 Developing students’ digital literacies for living and working in 21st century is a global issue (Lee 2014). In the UK there have been calls for a greater focus on digital literacy in higher education from the QAA (2014), NUS (n.d.) and House of Lords ...
Bennett, Elizabeth
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Key to Stabilizing House Prices: Bring Them Down [PDF]
, 2008 This report states that bringing about the rapid adjustment of house prices to trend levels is the best means of returning stability to the housing market.
Dean Baker
core
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
I grow so weary of the sound of screams : The Real Ghosts of Gettysburg [PDF]
, 2012 Down on Baltimore Street, in the front yard of the sprawling complex that calls itself the Farnsworth House, a tombstone used to sit. It was greyish-white, tall and arched at the top.
Rudy, John M.
core +1 more source
Distribution of catecholamine fibers in the cochlear nucleus of horseshoe bats and mustache bats [PDF]
, 1988 The glyoxylic-acid-induced fluorescence technique was applied to demonstrate patterns of catecholaminergic innervation within the auditory brainstem of echolocating bats and the house mouse.
Björklund +38 more
core +1 more source