Results 41 to 50 of about 1,354,963 (295)
Cloud Migration: A Case Study of Migrating an Enterprise IT System to IaaS
, 2010 This case study illustrates the potential benefits and risks associated with the migration of an IT system in the oil & gas industry from an in-house data center to Amazon EC2 from a broad variety of stakeholder perspectives across the enterprise, thus ...
Greenwood, David +2 more
core +3 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A critical focus on digital literacies [PDF]
, 2015 Developing students’ digital literacies for living and working in 21st century is a global issue (Lee 2014). In the UK there have been calls for a greater focus on digital literacy in higher education from the QAA (2014), NUS (n.d.) and House of Lords ...
Bennett, Elizabeth
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
I grow so weary of the sound of screams : The Real Ghosts of Gettysburg [PDF]
, 2012 Down on Baltimore Street, in the front yard of the sprawling complex that calls itself the Farnsworth House, a tombstone used to sit. It was greyish-white, tall and arched at the top.
Rudy, John M.
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
MedUNABRESUMEN Introducción. El envejecimiento poblacional ha incrementado la prevalencia de enfermedades crónicas como el trastorno neurocognoscitivo mayor, la multimorbilidad, la polifarmacia y con esto la probabilidad de prescripciones potencialmente ...
Ana Carolina Gama-González +3 more
doaj +1 more source
A Model for Out-of-Hospital Multispecialty Emergency Medicine: Accomplishments and Challenges
Health Services Insights, 2018 Home care has been traditionally considered as an important type of medical service. “SOS Doctors” is a Greek organization providing out-of-hospital multispecialty emergency medicine services the past 25 years. Its services mainly meet the demands of the
George Theocharis +6 more
doaj +1 more source
Footprint, 2023 The digital turn in architecture seems to have displaced the house as a paradigm for architectural theory. Omitting the house, and with it, housing and dwelling as key sites for the reconstitution of the discipline, recent theorisations of the digital ...
Dirk Van den Heuvel, Nelson Mota
doaj +1 more source