Results 41 to 50 of about 77,829 (251)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Uso de medicamentos potencialmente inadecuados en pacientes mayores con necesidades de atención paliativa en atención domiciliaria. Estudio transversal

MedUNAB
RESUMEN Introducción. El envejecimiento poblacional ha incrementado la prevalencia de enfermedades crónicas como el trastorno neurocognoscitivo mayor, la multimorbilidad, la polifarmacia y con esto la probabilidad de prescripciones potencialmente ...
Ana Carolina Gama-González, María Camila Garcés-Medina, Sandra Milena Castelblanco-Toro, Diego Andrés Chavarro-Carvajal   +3 more
doaj   +1 more source

A Model for Out-of-Hospital Multispecialty Emergency Medicine: Accomplishments and Challenges

Health Services Insights, 2018
Home care has been traditionally considered as an important type of medical service. “SOS Doctors” is a Greek organization providing out-of-hospital multispecialty emergency medicine services the past 25 years. Its services mainly meet the demands of the
George Theocharis, Konstantinos S Kechagias, Michael Oikonomou, Stamatia Chorepsima, Dionisis Rodis, Ioannis Salpigktis, Matthew E Falagas   +6 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

POGOe: Healthy Ager Life History Project

MedEdPORTAL, 2007
This resource trains students how to gather a life history from a “healthy ager,” someone who is defined as being over the age of 60. Students are trained in class and then meet with an assigned older adult to conduct the life history.
Lynn Bickley
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Acceptability and feasibility of a comprehensive fall prevention model for independent older adults: A qualitative evaluation

International Journal of Nursing Studies Advances
Background: Falls amongst the elderly represent a global public health challenge because of their potential to cause illness, death, and reduce the autonomy of this group.
Francisca Marquez-Doren, Camila Lucchini-Raies, Claudia Alcayaga, Claudia Bustamante, Marcela González-Agüero   +4 more
doaj   +1 more source

Locomotion difficulty and need for home care: a cross-sectional study [PDF]

Revista de Saúde Pública
OBJECTIVE To investigate home visits by physicians or nurses for consultations and procedures and associated factors in families with people with mobility difficulties and need for home care.
Rogério da Silva Linhares, Elaine Thumé, Maria Laura Vidal Carrett, Everton José Fantinel, Maria Aurora Dropa Chrestani Cesar, Elaine Tomasi   +5 more
doaj   +1 more source