Results 41 to 50 of about 79,873 (251)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Uso de medicamentos potencialmente inadecuados en pacientes mayores con necesidades de atención paliativa en atención domiciliaria. Estudio transversal

MedUNAB
RESUMEN Introducción. El envejecimiento poblacional ha incrementado la prevalencia de enfermedades crónicas como el trastorno neurocognoscitivo mayor, la multimorbilidad, la polifarmacia y con esto la probabilidad de prescripciones potencialmente ...
Ana Carolina Gama-González, María Camila Garcés-Medina, Sandra Milena Castelblanco-Toro, Diego Andrés Chavarro-Carvajal   +3 more
doaj   +1 more source

A Model for Out-of-Hospital Multispecialty Emergency Medicine: Accomplishments and Challenges

Health Services Insights, 2018
Home care has been traditionally considered as an important type of medical service. “SOS Doctors” is a Greek organization providing out-of-hospital multispecialty emergency medicine services the past 25 years. Its services mainly meet the demands of the
George Theocharis, Konstantinos S Kechagias, Michael Oikonomou, Stamatia Chorepsima, Dionisis Rodis, Ioannis Salpigktis, Matthew E Falagas   +6 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A Posthospitalization Home Visit Curriculum for Pediatric Patients

MedEdPORTAL, 2020
Introduction Home visits allow physicians to develop a deeper understanding of patients' homes and community, enhance physician-patient connectedness, and improve physician treatment plans for patients.
Eric Balighian, Michael Burke, Amy Davis, Jeffrey Chinsky, Megan M. Tschudy, Jamie Perin, Janet R. Serwint   +6 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

POGOe: Healthy Ager Life History Project

MedEdPORTAL, 2007
This resource trains students how to gather a life history from a “healthy ager,” someone who is defined as being over the age of 60. Students are trained in class and then meet with an assigned older adult to conduct the life history.
Lynn Bickley
doaj   +1 more source

Befriending the Darkness: L.M. Montgomery's Lived Theodicy in Anne's House of Dreams

Journal of L.M. Montgomery Studies, 2021
In Anne's House of Dreams, which Elizabeth Epperly calls Montgomery's most philosophical novel, Montgomery delves into painful topics of loss, suicide, bad marriages, ill-timed love, poverty, and the beautiful-terrible consequences of duty. The result is
Brenton D.G. Dickieson
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source