Results 41 to 50 of about 17,040 (303)

Genetic Food Futures

open access: yesExchanges, 2021
The aim of this article is to offer an answer to the question: How can we improve public engagement in the genetically modified organisms debate? It will describe the models of Public Understanding of Science and Public Engagement with Science.
Catherine Price
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Oral Evidence Submission - House of Lords Communications Committee: Public Service Broadcasting in the Age of Video on Demand [PDF]

open access: yes, 2019
House of Lords Communications Committee, Tue 02 Apr 2019. Subject: Public service broadcasting in the age of video on demand Witnesses: Professor Patrick Barwise, Emeritus Professor of Management and Marketing, London Business School Professor ...
House of Lords Communications Committee
core  

FIBROSA PRZECIW FAIRBAIRN - POLSKA SPÓŁKA, IZBA LORDÓW I PRAWO RZYMSKIE

open access: yesZeszyty Prawnicze, 2017
Fibrosa v. Fairbairn. Polish Company, House of Lords and the Roman Law Summary This paper deals w ith the development of the British doctrine of unjust enrichm ent, influenced to some extent by condictiones of the Rom an law.
Łukasz Marzec
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

House of Lords evidence paper: waste reduction [PDF]

open access: yes, 2008
Dr Chapman's developing international profile has positioned him as a leader in sustainable design teaching, research and scholarly activity, in both academic and industrial contexts.
Chapman, Jonathan
core  

House of Lords in the UK state system in the XIX century: «the doctrine of Salisbury»

open access: yesRUDN Journal of Law, 2014
The article is devoted to the evolution of the state system of the United Kingdom. The author highlights that the construction of the UK state system, established by the beginning of the XIX century, gave to the House of Lords conservative, stabilizing ...
V A Tomsinov
doaj  

Bikameralism in the Countries of the British Commonwealth of the Nations: Retrospective Analysis / Бикамерализм в странах Британского Содружества Наций: ретроспективный анализ

open access: yesBeneficium, 2019
The article discusses the evolution of bicameral legislatures of the British Commonwealth Countries in the twentieth century in the context of transforming the British Empire and the world experience of refusing or reducing the role of the Upper Houses ...
Elena A. Makarova / Елена А. Макарова
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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