Results 121 to 130 of about 1,131,712 (326)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Adequacy of Current Succession Law in Light of the Constitution and Policy Considerations [PDF]

, 2010
In this article, Gerald R. Ford’s counsel during Ford’s confirmation to the vice presidency under the Twenty-Fifth Amendment recounts the process, including investigations into Ford as part of the process and the confirmation hearings in the Senate and ...
Becker, Benton
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Rancang Bangun Standar Kinerja Anggota Dewan Perwakilan Rakyat Republik Indonesia [PDF]

, 2015
As an attempt to support the performance and improvement of the image of the House of Representatives in carrying out their duties, it is important to establish performance standards for each member of Parliament as dominant individual running their ...
Affandi, M. J. (M), Lestari, R. S. (Rizqi), Syarief, R. (Rizal)   +2 more
core  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Party leadership fights in the House of Representatives : the causes of conflict, 1895-1955.

, 1976
Maureen Roberts Romans
openalex   +2 more sources

Representatives and Senators: Trends in Member Characteristics Since 1945 [PDF]

, 2012
[Excerpt] This report provides profiles of Senators and Representatives in selected Congresses since 1945. It includes data based on Representatives and Senators serving on the first day of the 79th, 82nd, 87th, 92nd, 97th, 102nd, and 107th – 112th ...
Petersen, R. Eric
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The rise of partisanship and super-cooperators in the U.S. House of Representatives. [PDF]

PLoS One, 2015
Andris C, Lee D, Hamilton MJ, Martino M, Gunning CE, Selden JA.   +5 more
europepmc   +1 more source