Results 71 to 80 of about 1,131,712 (326)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Oversight Role Of Legislative Institutions In Emergency Situations (Comparison Of Indonesia With The United States)

Constitutionale
An emergency situation disrupts the normal functioning of a country, rendering standard laws and procedures ineffective. In such cases, extraordinary measures are required, and the President, as the executive authority, is granted significant powers to ...
Rizqya Nafila Putri, Muhammad Ali Ausath   +1 more
doaj   +1 more source

Analisis Kualitas Layanan Penyerapan Aspirasi Anggota DPR RI Dengan Pendekatan Quality Function Deployment (QFD)

Jurnal Sistem dan Manajemen Industri, 2017
Public satisfaction can be achieved if the government apparatus directly involved in the service, can understand and appreciate and wish to perform excellent service.
Rizal Sarifuddin
doaj   +1 more source

Florida House of Representatives District 78 Tribute [PDF]

, 2014
NSU 50th Anniversaryhttps://nsuworks.nova.edu/nsudigital_proclamations/1001/thumbnail ...
United States House of Representatives
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Transparansi dan Partisipasi Publik dalam Rekrutmen Calon Hakim Konstitusi

Jurnal Konstitusi, 2016
Recruitment is not an arena of  “hazing”  and  the  addition  of  bureaucracy  but a forum to explore the nature of integrity, capability, and independence of the candidates for constitutional judges.
Winda Wijayanti, Nuzul Quraini M, Siswantana Putri R   +2 more
doaj   +1 more source

Congressional Shaw Proclamation [PDF]

, 1999
NSU 35th Anniversaryhttps://nsuworks.nova.edu/nsudigital_proclamations/1045/thumbnail ...
United States House of Representatives
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Florida House of Representatives District 85 Proclamation [PDF]

, 2013
NSU 50th Anniversaryhttps://nsuworks.nova.edu/nsudigital_proclamations/1033/thumbnail ...
United States House of Representatives
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source