Results 131 to 140 of about 958,686 (317)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Swiss Household Panel (SHP). Data management with SPSS
This document provides users of the Swiss Household Panel (SHP) data with step-by-step instructions and best practices, while also highlighting common pitfalls when using SPSS for SHP data management.
Ryser, Valérie-Anne, Lebert, Florence
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Household Characteristics Associated with Stunting
, 2021 The Household Characteristics Associated with Stunting publication by the National Information Platform for Food Security and Nutrition (NIPN) investigates the household-level factors associated with stunting among children in Kenya.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Light-Weighting and Comparative Simulation Analysis of the Forearm of Welding Robots
ActuatorsThe light-weighting of a robotic arm is an important aspect of robot research. In the operation of existing welding robots, excessive vibrations in the welding actuators have been observed, which lead to reduced welding precision and work efficiency. The
Hongchen Pang +3 more
doaj +1 more source
Continuous Household Survey, 1986
, 1995 copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Policy Planning and Research Unit (Northern Ireland), Central Survey Unit
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Household decisions on whether to save or spend play a key role in the outlook for aggregate demand. A range of factors could help to explain the fall in the household saving ratio over the period 1995 to 2007.
Berry, Stuart +2 more
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Continuous Household Survey, 1988
, 1995 copyright UK Data Service and data collection copyright owner.The Continuous Household Survey (CHS) is one of the largest continuous surveys carried out in Northern Ireland.
Policy Planning and Research Unit (Northern Ireland), Central Survey Unit
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source