Results 31 to 40 of about 958,686 (317)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells

Scientific Reports
Current alopecia treatments have side effects and limited efficacy, highlighting the need for better alternatives. Estrogen and estrogen receptor alpha (ERα)-targeting therapies have shown promise in addressing female-pattern hair loss, outperforming ...
Heena Rim, Jaeyoon Kim, Jang Ho Joo, Sung Hyun Kim, Yun-Ho Choi, Jae Young Shin, Mi Hee Kwack, So Young Lee, Seung-Hyun Jun, Young Kwan Sung, Eui Taek Jeong, Nae Gyu Kang   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Verification of the association between cognitive decline and olfactory dysfunction using a DEmentia screening kit in subjects with Alzheimer's dementia, mild cognitive impairment, and normal cognitive function (DESK study): A multicenter, open-label, interventional study

eNeurologicalSci, 2022
Background and purpose: Olfactory dysfunction may be an early symptom of degenerative neurological disorders such as mild cognitive impairment (MCI), which may progress to cognitive decline and Alzheimer's disease (AD).
Takahiro Fukumoto, Toshifumi Ezaki, Katsuya Urakami   +2 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Efficacy of Vitamin B12 and Adenosine Triphosphate in Enhancing Skin Radiance: Unveiled with a Drug–Target Interaction Deep Learning-Based Model

Current Issues in Molecular Biology
Skin radiance is crucial for enhancing facial attractiveness and is negatively affected by factors like hyperpigmentation and aging-related changes. Current treatments often lack comprehensive solutions for improving skin radiance.
Hyeyeon Chun, Hyejin Lee, Jongwook Kim, Hyerin Yeo, Kyongeun Hyung, Dayoung Song, Moonju Kim, Seung-Hyun Jun, Nae-Gyu Kang   +8 more
doaj   +1 more source

Characterization of bacterial communities associated with blood-fed and starved tropical bed bugs, Cimex hemipterus (F.) (Hemiptera): a high throughput metabarcoding analysis

Scientific Reports, 2021
With the development of new metagenomic techniques, the microbial community structure of common bed bugs, Cimex lectularius, is well-studied, while information regarding the constituents of the bacterial communities associated with tropical bed bugs ...
Li Lim, Abdul Hafiz Ab Majid
doaj   +1 more source

Household debt and the European crisis. ECRI Research Report No. 13, June 2013 [PDF]

, 2013
The fall in economic output all over Europe since 2008 has had important consequences for household liabilities. Major growth in demand and supply for household credit products has generated an increase in household debt, which contributed to growth ...
Chmelar, Ales
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Fine Wrinkle Improvement through Bioactive Materials That Modulate EDAR and BNC2 Gene Expression

Biomolecules
Skin aging is a multifaceted biological phenomenon influenced by a combination of intrinsic or extrinsic factors. There is an increasing interest in anti-aging materials including components that improve skin wrinkles. Despite the availability of several
Seonju Lee, Sanghyun Ye, Mina Kim, Hyejin Lee, Seung-Hyun Jun, Nae-Gyu Kang   +5 more
doaj   +1 more source