Results 61 to 70 of about 531,950 (237)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color

Nature Communications
Evidence for adaptation of human skin color to regional ultraviolet radiation suggests shared and distinct genetic variants across populations. However, skin color evolution and genetics in East Asians are understudied. We quantified skin color in 48,433
Beomsu Kim, Dan Say Kim, Joong-Gon Shin, Sangseob Leem, Minyoung Cho, Hanji Kim, Ki-Nam Gu, Jung Yeon Seo, Seung Won You, Alicia R. Martin, Sun Gyoo Park, Yunkwan Kim, Choongwon Jeong, Nae Gyu Kang, Hong-Hee Won   +14 more
doaj   +1 more source

Household Surveys

, 2008
Household surveys play a pivotal role in empirical economics. Cross-section and longitudinal surveys are regularly conducted throughout the globe. A description of survey design and sampling methods provides the foundation for discussing survey errors.
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Super-resolution mapping reveals NAD⁺-delivering probiotic extracellular vesicles as nanotherapeutics for organelle protection and inflammation control

Journal of Nanobiotechnology
Background Lactobacillus plantarum (L. plantarum) is a probiotic bacterium with diverse health-promoting effects. Recent evidence suggests that these benefits are mediated by extracellular vesicles (EVs) secreted by the bacterium; however, the underlying
Ga-eun Go, Minjae Kang, Bo Kyoung Hwang, Sangoh Choi, Uidon Jeong, Eunyoung Moon, Sang-Hee Lee, Seongsu Kang, Nae-Gyu Kang, Yunkwan Kim, Euitaek Jeong, Doory Kim   +11 more
doaj   +1 more source

Timed-Release Silica Microcapsules for Consistent Fragrance Release in Topical Formulations

Applied Sciences
Microcapsules are widely utilized in various applications to preserve active ingredients for prolonged durations while enabling controlled release. However, limited release of active ingredients often hampers their effectiveness in daily-use products. In
Junseok Yeom, Minseo Kang, Areum Goh, Jeonghoon Jeon, Woo Sun Shim, Nae Gyu Kang   +5 more
doaj   +1 more source

Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging

Asian Journal of Pharmaceutical Sciences, 2014
Glyceryl monooleate (GMO) is a polar lipid that can exist in various liquid crystalline phases in the presence of different amounts of water. It is regarded as a permeation enhancer due to its amphiphilic property.
Dae Gon Lim, Won-Wook Jeong, Nam Ah Kim, Jun Yeul Lim, Seol-Hoon Lee, Woo Sun Shim, Nae-Gyu Kang, Seong Hoon Jeong   +7 more
doaj   +1 more source