Results 101 to 110 of about 675,818 (327)

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Bilateral Distal Radius Fractures in a 12-Year-Old Boy after Household Electrical Shock: Case Report and Literature Summary

Case Reports in Medicine, 2014
Background. Fracture resulting from household electric shock is uncommon. When it occurs, it is usually the result of a fall; however, electricity itself can cause sufficient tetany to produce a fracture.
Norman Stone, Mara Karamitopoulos, David Edelstein, Jenifer Hashem, James Tucci   +4 more
doaj   +1 more source

Study protocol for a cluster-randomized controlled trial of an NCD access to medicines initative: Evaluation of Novartis Access in Kenya [PDF]

, 2016
INTRODUCTION: Novartis recently launched Novartis Access, an initiative to provide a basket of reduced price medicines for non-communicable diseases (NCDs) to be sold through the public and private nonprofit sectors in programme countries.
Ashigbie, Paul G., Laing, Richard, Onyango, Monica A., Rockers, Peter C., Vian, Taryn, Wirtz, Veronika J.   +5 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Poor Relief, Informal Assistance, and Short Time During the Lancashire Cotton Famine [PDF]

, 1997
[Excerpt] This paper presents new evidence concerning the importance of poor relief as a source of income assistance for unemployed operatives during the Lancashire cotton famine.
Boyer, George R
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Spending on Pets: Tails from the Consumer Expenditure Survey [PDF]

, 2013
Nearly three-quarters of U.S. households own pets. There are about 218 million pets in the United States, not counting several million fish. Pet ownership crosses many demographic boundaries, with Americans of different ages and levels of wealth ...
Henderson, Steven
core   +1 more source

Smart homes and their users:a systematic analysis and key challenges [PDF]

, 2015
Published research on smart homes and their users is growing exponentially, yet a clear understanding of who these users are and how they might use smart home technologies is missing from a field being overwhelmingly pushed by technology developers ...
A Cesta, A Crabtree, A McLean, A Venkatesh, A-G Paetz, AECOM and OFGEM, AS Taylor, C Berg, Charlie Wilson, D Geelen, D Gracanin, DJ Cook, F Perez, FK Aldrich, G Demiris, G Demiris, G Wallenborn, G Wood, H Allcott, H Rohracher, HJ Richardson, I Røpke, J Axsen, JG Koomey, JKW Wong, JT Giger, JV Hoof, K Herter, K Jeong, L Baillie, L Bainbridge, L Swan, M Chan, M Chan, M Friedewald, M Martiskainen, P Heath, P Palensky, P Rashidi, R Bernhaupt, R Orpwood, R Schwartz-Cowan, R Silverstone, Richard Hauxwell-Baldwin, S Darby, S Darby, S Davidoff, S Howard, S Hussain, S Nyborg, S Solaimani, SCR Lewis, SH Park, SK Das, SS Dam van, T Enright, T Hargreaves, T Hargreaves, T Koskela, Tom Hargreaves, V Haines, WK Edwards, Y Strengers, Y-J Lin   +63 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source