Results 181 to 190 of about 733,661 (301)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Socio-demographic and geographic disparities in HIV prevalence, HIV testing and treatment coverage: An analysis of 108 national household surveys in 33 African countries. [PDF]

J Int AIDS Soc
Allorant A, Kuchukhidze S, Stannah J, Xia Y, Masuku SS, Ekanmian GK, Imai-Eaton JW, Maheu-Giroux M.   +7 more
europepmc   +1 more source

Trends and Determinants of Full Immunisation among Children Aged 12-23 Months: Analysis of Pooled Data from Mozambican Household Surveys between 1997 and 2015. [PDF]

Int J Environ Res Public Health, 2023
Cassocera M, Augusto O, Chissaque A, Guimarães EL, Shulock K, de Deus N, Martins MRO.   +6 more
europepmc   +1 more source

Creating a 1995 OHS and a Combined OHS-IES Database in STATA [PDF]

This paper builds on Technical Paper 2003: 1. It provides a technical description of how the 1995 October Household Survey (OHS) dataset was created in STATA and subsequently merged with the 1995 Income and Expenditure Survey (IES) dataset to form a ...
Pauw, Kalie
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Heated tobacco product use prevalence and temporal trends among the German population: a series of representative cross-sectional household surveys, 2018-2023. [PDF]

BMJ Open
Keller AM, Klosterhalfen S, Kastaun S, Kotz D.   +3 more
europepmc   +1 more source

A comparison of two population-based household surveys in Uganda for assessment of violence against youth. [PDF]

PLoS One, 2021
Currie DW, Apondi R, West CA, Biraro S, Wasula LN, Patel P, Hegle J, Howard A, Benevides de Barros R, Durant T, Chiang LF, Voetsch AC, Massetti GM.   +12 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Factors associated with mothers' health care-seeking behaviours for childhood fever in Burkina Faso: findings from repeated cross-sectional household surveys. [PDF]

Glob Health Res Policy, 2022
Badolo H, Bado AR, Hien H, Méda N, Susuman AS.   +4 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source