Results 201 to 210 of about 733,661 (301)

Multidimensional well-being of US households at a fine spatial scale using fused household surveys. [PDF]

Sci Data
Ummel K, Poblete-Cazenave M, Akkiraju K, Graetz N, Ashman H, Kingdon C, Herrera Tenorio S, Singhal AS, Cohen DA, Rao ND.   +9 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Care Seeking and Treatment of Febrile Children with and without Danger Signs of Severe Disease in Northern Uganda: Results from Three Household Surveys (2018-2020). [PDF]

Am J Trop Med Hyg, 2022
Awor P, Kimera J, Brunner NC, Athieno P, Tumukunde G, Angiro I, Signorell A, Delvento G, Lee T, Amutuhaire M, Opigo J, Kaggwa FM, Kagwire F, Nakiganda J, Burri C, Lengeler C, Hetzel MW.   +16 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Antenatal care coverage and early childhood mortality in Zimbabwe: new interpretations from nationally representative household surveys. [PDF]

Health Promot Int
Musiwa AS, Sinha V, Hanley J, Ruiz-Casares M.   +3 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Assessing food consumed away from home in low-and middle-income countries by developing specific modules for household surveys: Experimental evidence from Vietnam and Burkina Faso. [PDF]

PLoS One
Landais E, Pelloquin R, Maître d'Hôtel E, Truong Tuyet M, Hoang Thu N, Bui Thi Thao Y, Do Thi Phuong H, Thu TTT, Somé J, Béné C, Verger EO.   +10 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Gestational weight gain at the national, regional, and income group levels based on 234 national household surveys from 70 low-income and middle-income countries. [PDF]

PLOS Glob Public Health
Costa JC, Wang D, Wang M, Liu E, Partap U, Cliffer I, Fawzi WW.   +6 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source