Results 261 to 270 of about 1,570,129 (332)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Prevalence, spatial and temporal distribution of tungiasis in the Kilifi Health and Demographic Surveillance System (KHDSS) in Kenya. [PDF]

BMJ Glob Health
Ouma N, Muchiri SK, Nyundo C, Walumbe D, Nyaguara A, Maia M, Adetifa I, Orindi B, Bejon P, Fillinger U, Elson L.   +10 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

A Machine Learning Approach to Predicting Household Smoke Exposure Risk in Somalia: An Analysis With SHAP Explanations. [PDF]

Environ Health Insights
Omar MA, Hassan YSA, Ali AS, Ahmed MM.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

What Makes Household Sanitation Systems Resilient to Floods? Evidence from Ethiopia, Uganda, and Nepal. [PDF]

ACS ES T Water
Kohlitz J, Geremew A, Okurut K, Poudel P, Ghimire A, Nijhawan A, Valenzuela A, Falletta J, Manandhar-Sherpa A, Willetts J, Howard G.   +10 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Dynamics of household water use determinants in selected Local Government Areas in Oyo Zone of Oyo State Nigeria. [PDF]

Sci Rep
Oyelami AA, Ogunbode TO, Owoeye MO.
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Mapping inequities in safe water access: a spatial and geographically weighted regression analysis of unimproved water source use in sub-Saharan Africa. [PDF]

J Health Popul Nutr
Yitageasu G, Gebrehana AK, Asnake AA, Kase BF, Tigabie M, Demoze L.   +5 more
europepmc   +1 more source