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Evidence based selection of housekeeping genes.
PLoS ONE, 2007 For accurate and reliable gene expression analysis, normalization of gene expression data against housekeeping genes (reference or internal control genes) is required. It is known that commonly used housekeeping genes (e.g.
Hendrik J M de Jonge +9 more
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Housekeeping genes in cancer: normalization of array data
BioTechniques, 2005 Biological maintenance of cells under variable conditions should affect gene expression of only certain genes while leaving the rest unchanged. The latter, termed “housekeeping genes,” by definition must reflect no change in their expression levels ...
Anis H. Khimani +9 more
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Housekeeping genes in prostate tumorigenesis [PDF]
International Journal of Cancer, 2009 AbstractHousekeeping (HK) genes are involved in basic cellular functions and tend to be constitutively expressed across various tissues and conditions. A number of studies have analyzed the value of HK genes as an internal standard for assessing gene expression, but the role of HK genes in cancer development has never been specifically addressed.
Jinyoung, Byun +2 more
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Human housekeeping genes are compact [PDF]
Trends in Genetics, 2003 We identify a set of 575 human genes that are expressed in all conditions tested in a publicly available database of microarray results. Based on this common occurrence, the set is expected to be rich in "housekeeping" genes, showing constitutive expression in all tissues.
Eisenberg, Eli, Levanon, Erez Y.
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Divergent and convergent evolution of housekeeping genes in human–pig lineage [PDF]
PeerJ, 2018 Housekeeping genes are ubiquitously expressed and maintain basic cellular functions across tissue/cell type conditions. The present study aimed to develop a set of pig housekeeping genes and compare the structure, evolution and function of housekeeping ...
Kai Wei, Tingting Zhang, Lei Ma
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Cumhuriyet Science Journal, 2022 Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is an effective, reproducible, and dependable method for evaluating and targeting expression of genes.
Emin Ufuk Karakaş +2 more
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Repetitive sequence environment distinguishes housekeeping genes [PDF]
Gene, 2007 Housekeeping genes are expressed across a wide variety of tissues. Since repetitive sequences have been reported to influence the expression of individual genes, we employed a novel approach to determine whether housekeeping genes can be distinguished from tissue-specific genes by their repetitive sequence context.
C Daniel, Eller +5 more
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Regulatory architecture of housekeeping genes is driven by promoter assemblies
Cell Reports, 2023 Summary: Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes that encode housekeeping functions,
Marion Dejosez +11 more
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Isolation of Housekeeping Genes on Durik-durik (Syzygium sp)
Biosaintifika: Journal of Biology & Biology Education, 2018 Housekeeping gene is a gene expressed with a fixed level and in abundant amounts under various conditions. After validation, the housekeeping gene can be used as an internal control to normalize gene expression data.
Dewi Indriyani Roslim +7 more
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Selection of housekeeping genes for gene expression studies in the adult rat submandibular gland under normal, inflamed, atrophic and regenerative states [PDF]
, 2008 Background: Real-time PCR is a reliable tool with which to measure mRNA transcripts, and provides valuable information on gene expression profiles. Endogenous controls such as housekeeping genes are used to normalise mRNA levels between samples for ...
Nicholas Silver +5 more
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