Results 151 to 160 of about 174,210 (250)

Which One Would You Choose?-Investigation of Widely Used Housekeeping Genes and Proteins in the Spinal Cord of an Animal Model of Amyotrophic Lateral Sclerosis. [PDF]

NeuroSci
Epplen ASC, Stahlke S, Theiss C, Matschke V.   +3 more
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Stability and suitability of housekeeping genes in phlebotomine sand flies. [PDF]

Sci Rep
Sassù F, Vomáčková Kykalová B, Vieira CS, Volf P, Loza Telleria E.   +4 more
europepmc   +1 more source

Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes. [PDF]

Nat Commun, 2021
Shoaib M, Chen Q, Shi X, Nair N, Prasanna C, Yang R, Walter D, Frederiksen KS, Einarsson H, Svensson JP, Liu CF, Ekwall K, Lerdrup M, Nordenskiöld L, Sørensen CS.   +14 more
europepmc   +1 more source

Illuminating Mitochondrial RNA G‐Quadruplexes as Structural Brakes on RNA Granule Assembly and OXPHOS

Advanced Science, EarlyView.
A new fluorescent probe, MitoQUMA, brings mitochondrial RNA G‐quadruplexes (mtRNA G4s) into view in live cells. This tool reveals that excessive mtRNA G4 formation halts mitochondrial RNA granule (MRG) assembly, opposite to the phase‐separation role of cytoplasmic RNA G4s. A chemical genetic screen further identifies a Wnt/β‐catenin–GRSF1–mtRNA G4 axis
Gui‐Xue Tang, Jia‐Tong Yan, Mao‐Lin Li, Cui Zhou, Jian Wang, Shuo‐Bin Chen, Zhi‐Shu Huang, Jia‐Heng Tan   +7 more
wiley   +1 more source

Expression Profiles of Housekeeping Genes and Tissue-Specific Genes in Different Tissues of Chinese Sturgeon (Acipenser sinensis). [PDF]

Animals (Basel)
Li Y, Lv Y, Cheng P, Jiang Y, Deng C, Wang Y, Wen Z, Xie J, Chen J, Shi Q, Du H.   +10 more
europepmc   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, EarlyView.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Stability assessment of housekeeping genes for qRT-PCR in Yersinia enterocolitica cultured at 22°C and 37°C. [PDF]

Microbiol Spectr
Li C, Zhou L, Ma X, Zhu L, Li J, Meng L, Han M, Wang D, Shen H, Liu C.   +9 more
europepmc   +1 more source

A CLE11b‐CLE16 Signaling Relay Mediates Root‐Shoot‐Root Crosstalk for Drought Adaptation in Common Bean

Advanced Science, EarlyView.
A novel root‐shoot‐root signaling relay, mediated by CLE peptides, coordinates drought adaptation in common bean. Root‐derived PvCLE11b translocates acropetally to leaves, inducing PvCLE16 expression via PvTCP10. Leaf‐accumulated PvCLE16 triggers stomatal closure and translocates basipetally to modulate root architecture.
Xinyang Wu, Shiyuan Tao, Zhuoyi Wang, Ting Sun, Zixin Zhang, Su Yang, Min Xu, Chenyi Huang, Siyi Wang, Xubo Ke, Chenze Lu, Kang Ning, Pei Xu   +12 more
wiley   +1 more source

Developmental and Housekeeping Genes: Two Types of Genetic Organization in the Drosophila Genome. [PDF]

Int J Mol Sci
Zhimulev I, Vatolina T, Levitsky V, Tsukanov A.   +3 more
europepmc   +1 more source