What are housekeeping genes? [PDF]
PLoS Computational Biology, 2022 The concept of "housekeeping gene" has been used for four decades but remains loosely defined. Housekeeping genes are commonly described as "essential for cellular existence regardless of their specific function in the tissue or organism", and "stably ...
Chintan J Joshi +4 more
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Identification of Suitable Meloidogyne spp. Housekeeping Genes [PDF]
Journal of Nematology, 2019 Gene expression studies often require reliable housekeeping (HK) genes to accurately capture gene expression levels under given conditions. This is especially true for root-knot nematodes (RKN, Meloidogyne spp.), whose drastic developmental changes are ...
Hu Weiming, DiGennaro Peter M.
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Do housekeeping genes exist? [PDF]
PLoS ONE, 2015 The searching of human housekeeping (HK) genes has been a long quest since the emergence of transcriptomics, and is instrumental for us to understand the structure of genome and the fundamentals of biological processes.
Yijuan Zhang, Ding Li, Bingyun Sun
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Regulatory architecture of housekeeping genes is driven by promoter assemblies [PDF]
Cell Reports, 2023 Summary: Genes that are key to cell identity are generally regulated by cell-type-specific enhancer elements bound by transcription factors, some of which facilitate looping to distant gene promoters. In contrast, genes that encode housekeeping functions,
Marion Dejosez +11 more
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Using RNA-seq to identify suitable housekeeping genes for hypoxia studies in human adipose-derived stem cells [PDF]
BMC Molecular and Cell Biology, 2023 Background Hypoxic culture conditions have been used to study the impact of oxygen deprivation has on gene expression in a number of disease models. However, hypoxia response elements present in the promoter regions of some commonly used housekeeping ...
Huan Ting Ong +2 more
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Evidence based selection of housekeeping genes.
PLoS ONE, 2007 For accurate and reliable gene expression analysis, normalization of gene expression data against housekeeping genes (reference or internal control genes) is required. It is known that commonly used housekeeping genes (e.g.
Hendrik J M de Jonge +9 more
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Identification of stable housekeeping genes for induced pluripotent stem cells and -derived endothelial cells for drug testing [PDF]
Scientific Reports, 2022 There are no validated housekeeping genes in induced pluripotent stem cells (iPSC) and derived endothelial iPSC (iPSC-EC). Thus a comparison of gene expression levels is less reliable, especially during drug treatments.
Sheena L. M. Ong +4 more
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Analysis of the stability of 70 housekeeping genes during iPS reprogramming [PDF]
Scientific Reports, 2020 Studies on induced pluripotent stem (iPS) cells highly rely on the investigation of their gene expression which requires normalization by housekeeping genes.
Yulia Panina +2 more
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Divergent and convergent evolution of housekeeping genes in human–pig lineage [PDF]
PeerJ, 2018 Housekeeping genes are ubiquitously expressed and maintain basic cellular functions across tissue/cell type conditions. The present study aimed to develop a set of pig housekeeping genes and compare the structure, evolution and function of housekeeping ...
Kai Wei, Tingting Zhang, Lei Ma
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Expression Profile of Housekeeping Genes and Tissue-Specific Genes in Multiple Tissues of Pigs [PDF]
Animals, 2022 Pigs have become an ideal model system for human disease research and development and an important farm animal that provides a valuable source of nutrition.
Xiangchun Pan +10 more
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