Results 211 to 220 of about 174,210 (250)

Housekeeping Genes as Internal Standards in Cancer Research

Molecular Diagnosis, 2004
Differences in gene expression are frequently encountered in malignant tissues, and have been intensively studied as they can reflect different experimental or clinical conditions. Quantification of the often subtle changes in messenger RNA content is performed through comparison with the expression of endogenous controls.
Nico, Janssens, Michel, Janicot, Tim, Perera, Annette, Bakker   +3 more
openaire   +2 more sources

Housekeeping Genes: A Gold Standard?

2004
Gene expression studies that aim at precision require normalization to an internal control or “housekeeping” gene. The greatest challenge in choosing an appropriate housekeeping gene is maintaining expression consistency during treatment.
Onno Bakker, Daphne C. Timmer
openaire   +1 more source

Gene Ontology based housekeeping gene selection for RNA-seq normalization

Methods, 2014
RNA-seq analysis provides a powerful tool for revealing relationships between gene expression level and biological function of proteins. In order to identify differentially expressed genes among various RNA-seq datasets obtained from different experimental designs, an appropriate normalization method for calibrating multiple experimental datasets is ...
Chien-Ming, Chen, Yu-Lun, Lu, Chi-Pong, Sio, Guan-Chung, Wu, Wen-Shyong, Tzou, Tun-Wen, Pai   +5 more
openaire   +2 more sources

Genome-wide identification of housekeeping genes in maize

Plant Molecular Biology, 2014
In the wake of recent progress of high throughput transcriptome profiling technologies, extensive housekeeping gene mining has been conducted in humans. However, very few studies have been reported in maize (Zea mays L.), an important crop plant, and none were conducted on a genome -wide level.
Feng, Lin, Lu, Jiang, Yuhe, Liu, Yuanda, Lv, Huixue, Dai, Han, Zhao   +5 more
openaire   +2 more sources

(TG/CA)_nRepeats in Human Housekeeping Genes

Journal of Biomolecular Structure and Dynamics, 2003
The unravelling of human genome sequence gives a new opportunity to investigate the role of repetitive sequences in gene regulation. Among the various types of repetitive sequences, the dinucleotide (TG:CA)(n) repeats are one of the most abundant in human genome and exhibit polymorphism.
Vineet K, Sharma, Chandrika, B-Rao, Anu, Sharma, Samir K, Brahmachari, Srinivasan, Ramachandran   +4 more
openaire   +2 more sources

How do ‘housekeeping’ genes control organogenesis?—unexpected new findings on the role of housekeeping genes in cell and organ differentiation

Journal of Plant Research, 2012
In recent years, an increasing number of mutations in what would appear to be 'housekeeping genes' have been identified as having unexpectedly specific defects in multicellular organogenesis. This is also the case for organogenesis in seed plants. Although it is not surprising that loss-of-function mutations in 'housekeeping' genes result in lethality ...
Tsukaya, Hirokazu, Byrne, Mary E., Horiguchi, Gorou, Sugiyama, Munetaka, Van Lijsebettens, Mieke, Lenhard, Michael (Prof. Dr.)   +5 more
openaire   +3 more sources

Housekeeping Gene Variability in the Liver of Alcoholic Patients

Alcoholism: Clinical and Experimental Research, 2011
Background:  Quantification of gene expression using reverse transcription‐quantitative polymerase chain reaction (RT‐qPCR) requires normalization to an endogenous reference gene termed housekeeping gene (HKG). Many of the commonly used HKGs are regulated and vary under experimental conditions and disease stages.
Hédia, Boujedidi, Laurence, Bouchet-Delbos, Anne-Marie, Cassard-Doulcier, Micheline, Njiké-Nakseu, Sophie, Maitre, Sophie, Prévot, Ibrahim, Dagher, Hélène, Agostini, Cosmin S, Voican, Dominique, Emilie, Gabriel, Perlemuter, Sylvie, Naveau   +11 more
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

Housekeeping genes are enriched in rheumatoid arthritis-related genes

AbstractHousekeeping genes are often considered to be stably expressed in any tissue, cell, or disease state, and the relationship between housekeeping genes and rheumatoid arthritis (RA) has never been systematically analyzed. Therefore we aimed to explore whether housekeeping genes are abnormally expressed in RA by analyzing 15 datasets that were ...
Wenhua Lv, Hao Tang, Guanglong Feng, Shuhao Zhang, Zhenwei Shang, Mingming Zhang, Rui Chen, Xiangshu Cheng, Xin Meng, Hongchao Lv, Ruijie Zhang   +10 more
openaire   +1 more source

Measurement of Housekeeping Genes in Human Placenta

Placenta, 2009
Cleal, J.K., Day, P.I., Hanson, M.A., Lewis, R.M.   +3 more
openaire   +3 more sources