Results 41 to 50 of about 156,333 (265)

Containers and grains: food storage and symbolism in the Central Balkans (Vinča period)

open access: yesDocumenta Praehistorica, 2011
Since Flannery, who showed that types and locations of storage facilities provide a variety of associations for explaining social change, the economic and social role of storage has been reviewed numerous times.
Boban Tripković
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

A Tentative Attempt to Estimate the Systemic Number of the Late Neolithic Vinča Culture Figurines

open access: yesEtnoantropološki Problemi, 2011
In this paper an attempt is made to estimate the number of figurines which were in "use" in households of the Late Neolithic Vinča culture. The number of accumulated figurines and houses is used as a starting point.
Marko Porčić
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Topos Home as Heterotopy in the Novel by M. Petrosyan “The House in Which…”

open access: yesФилологический класс, 2021
The article is devoted to the study of the topos home as a stable image with spatial characteristics in the book by M. Petrosyan “House in Which ...”. The aim of the article is to identify the possibility of functioning of the topos home in the novel as ...
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Research and conservation in Marina el-Alamein in 2014 and 2015 (Polish–Egyptian Conservation mission). Part one: The Southern Bath and central town square [PDF]

open access: yesPolish Archaeology in the Mediterranean, 2017
Activities undertaken by the Polish–Egyptian Conservation Mission to Marinael-Alamein in 2014 and 2015 included research and conservation in the public district of theancient town as well as in private houses.
Grzegorz Majcherek   +3 more
doaj   +1 more source

The life cycle of the houses in the final Late Copper Age horizon at Tell Yunatsite

open access: yesStudia Praehistorica, 2021
The article summarizes the accumulated information from the investigated 11 houses of the last Late Chalcolithic settlement at Tell Yunatsite. The Late Chalcolithic house is discussed both as a functional and a symbolically arranged place where real and
Velichka Mazanova   +2 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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