Results 51 to 60 of about 2,575,445 (348)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Architecture of The heritage buildings in Najaf and its role in promoting national identity

open access: yesمجلة الآداب, 2019
Heritage represents the living memory of the individual and society , it is cultural identity that people recognize about the privacy of people . That is the full record of human activity in a society preserved in the collective memory of the people . It
Abd Al-Satar Shnin Alganaby
doaj   +1 more source

Brass Art: A house within a house within a house within a house [PDF]

open access: yesJournal of Writing in Creative Practice, 2014
Abstract Performances from Brass Art (Lewis, Mojsiewicz, Pettican), captured at the Freud Museum, London, using Kinect laser scanning and Processing, reveal an intimate response to spaces and technologies. ‘A house within a house within a house within a house’ links historical and cultural representations of the double, the unconscious ...
Lewis, C, Mojsiewicz, K, Pettican, A
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Containers and grains: food storage and symbolism in the Central Balkans (Vinča period)

open access: yesDocumenta Praehistorica, 2011
Since Flannery, who showed that types and locations of storage facilities provide a variety of associations for explaining social change, the economic and social role of storage has been reviewed numerous times.
Boban Tripković
doaj   +1 more source

Essentials and Competencies of Construction from the Perspective of Islamic Teachings [PDF]

open access: yesInternational Multidisciplinary Journal of Pure Life, 2015
In Iran, and especially in recent years, the housing and construction market has flourished. In the meantime, we are witnessing that the observance of legal and Islamic issues in constructions, beautifying the face of cities and securing buildings are ...
Akram Asghari (Iran)   +1 more
doaj   +1 more source

Carbon Dioxide Production in Animal Houses: A literature review [PDF]

open access: yes, 2008
This article deals with carbon dioxide production from farm animals; more specifically, it addresses the possibilities of using the measured carbon dioxide concentration in animal houses as basis for estimation of ventilation flow (as the ventilation ...
Aarnink, A.J.A.   +6 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A Tentative Attempt to Estimate the Systemic Number of the Late Neolithic Vinča Culture Figurines

open access: yesEtnoantropološki Problemi, 2011
In this paper an attempt is made to estimate the number of figurines which were in "use" in households of the Late Neolithic Vinča culture. The number of accumulated figurines and houses is used as a starting point.
Marko Porčić
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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