Results 111 to 120 of about 3,653,103 (356)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Training gilts to use a feeder station [PDF]
Group housing of dry sows is compulsory in Europe from 2013 onwards. Many pig farmers who still have to convert to group housing fear the resulting demand on their ability to interact with individual animals.
Kiezebrink, M.C. +3 more
core +1 more source
, 1978 A device for exercising animals such as primates is described, which includes a cylindrical housing mounted for rotation about a horizontal axis of revolution and has a cylindrical treadway portion on which the animal treads while the drum is rotated by ...
Howard, W. H.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Is There a "Cage-Free" Lunch in U.S. Egg Production? Public Views of Laying-Hen Housing Attributes
Journal of Agricultural and Resource Economics, 2019 Animal welfareÐrelated production attributes are increasingly considered by U.S. consumers making food purchasing decisions and U.S. voters at the ballot box. This research considers U.S. consumer preferences for egg production attributes.
Daniel Ochs +3 more
doaj +1 more source
Journal of Neurophysiology, 2018 Teaching nonhuman primates the complex cognitive behavioral tasks that are central to cognitive neuroscience research is an essential and challenging endeavor. It is crucial for the scientific success that the animals learn to interpret the often complex
M. Berger +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Frontiers in Veterinary Science, 2017 Keel bone damage is a wide-spread welfare problem in laying hens. It is unclear so far whether bone quality relates to keel bone damage. The goal of the present study was to detect possible associations between keel bone damage and bone properties of ...
Sabine G. Gebhardt-Henrich +6 more
doaj +1 more source
Animals, 2019 Simple Summary Surgical castration of male piglets is societally criticized as it is painful and violates the integrity of the animals. Pork production with boars and immunocastrates are possible alternatives.
K. Kress +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source