Results 71 to 80 of about 2,340,256 (302)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A review of recent research outcomes on the housing of farmed domestic rabbits: reproducing does

World Rabbit Science, 2019
The housing of farmed animals is increasingly scrutinised by society and thereby subject to a change towards more animal-friendly systems. For rabbits, also kept as pets, there are no EC regulations regarding their housing under farming conditions.
Zsolt Szendrő, Angela Trocino, Steffen Hoy, Gerolamo Xiccato, Arantxa Villagrá, Luc Maertens   +5 more
doaj   +1 more source

An on-farm investigation of beef suckler herds using an animal welfare index (AWI) [PDF]

, 2010
peer-reviewedBackground: Beef suckler farms (194 farms throughout 13 counties) were assessed once with housed cattle and once with cattle at grass using an animal welfare index (AWI).
Veissier Isabelle, Mazurek Mickael, Daniel J Prendiville, Isabelle Veissier, Prendiville, Daniel, Crowe Mark A, Prendiville, Daniel J., Crowe, Mark A, Mickael Mazurek, Earley Bernadette, Crowe, Mark, Bernadette Earley, Veissier, Isabelle, Prendiville Daniel J, Earley, Bernadette, Mark A Crowe, Mazurek, Mickael   +16 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A Scoping Review: The Impact of Housing Systems and Environmental Features on Beef Cattle Welfare

Animals, 2020
Housing systems and environmental features can influence beef cattle welfare. To date, little information has been synthesized on this topic. The aim of this scoping review was to examine the relationship between housing and welfare status, so that beef ...
Rachel M. Park, Margaret Foster, Courtney L. Daigle   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Use of location tracking to link egg production with toe pecking injuries, feather quality, body mass in laying hens

Journal of Applied Poultry Research
Summary: The current study sought to validate a proxy for egg laying that could be used within cage-free housing systems towards breeding programs of laying hens.
M.J. Toscano, M. Neuditschko, S.G. Gebhardt-Henrich   +2 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Other title: Kansas Housing Resources Corporation press releases, 2012; Other title: Kansas Housing Resources Corporation news releases, 2012

, 2012
PUT THE TIME PERIOD COVERED HERE... e.g. January-December 2003; application/pdf; Annual cumulation of 2012 issuesGOVERNOR BROWNBACK PROCLAIMS APRIL FAIR HOUSING MONTH -- KCK Celebrates Grand Opening of New Senior Housing -- Mulvane Welcomes SUPER GREEN ...
Kansas Housing Resources Corporation.
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source