Results 101 to 110 of about 2,527,170 (342)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Affordable housing definitions and Section 106 contributions in England [PDF]

open access: yes, 2008
This paper examines whether Local Planning Authority definitions of affordable housing provide adequate clarity with which to negotiate affordable housing contributions with private sector house builders. The paper updates Government research, Delivering
Chapelhow, Steven   +2 more
core  

Housing and quality of life for migrant communities in western Europe: a capabilities approach [PDF]

open access: yes, 2013
Housing is an important determinant of quality of life and migrants are more likely to encounter poor quality housing than natives. This paper draws on the capabilities approach to welfare economics to examine how issues of housing and neighborhood ...
Anand, Paul   +2 more
core   +2 more sources

Optimization of mechanical properties in foamcrete reinforced with raw oil palm empty fruit bunch (EFB) fiber

open access: yesMATEC Web of Conferences, 2018
As Malaysia currently heading to biotechnology hub, it is expected that billions tons of palm oil by-products will be produced annually and normally been treated as waste disposal.
Musa Mazlina   +2 more
doaj   +1 more source

Incidence of Neurosis in a New Housing Estate [PDF]

open access: bronze, 1957
Fernando Martín   +2 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Influence of Energy Efficient Elements on Energy Saving in Residential Buildings: Case Study of Three Apartments in Penang

open access: yesMATEC Web of Conferences, 2014
This paper examined the energy consumption of energy efficient buildings, and ascertained the extent to which these buildings are efficient when compared to normal buildings. For this purpose, the early literature regarding energy efficient buildings and
Nejad Moghadam M.H.   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Burrowing apparatus [PDF]

open access: yes, 1968
A soil burrowing mole is described in which a housing has an auger blade wound around a front portion. This portion is rotatable about a housing longitudinal axis relative to an externally finned housing rear portion upon operation of driving means to ...
Hotz, G. M., Howard, E. A., Scott, R. F.
core   +1 more source

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